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Comment
. 2022 May 9;40(5):452-454.
doi: 10.1016/j.ccell.2022.04.008. Epub 2022 May 9.

Tissue residency of memory CD8+ T cells matters in shaping immunogenicity of ovarian cancer

Takemasa Tsuji  1 , Junko Matsuzaki  1 , Kunle Odunsi  2
Affiliations
Comment

Tissue residency of memory CD8+ T cells matters in shaping immunogenicity of ovarian cancer

Takemasa Tsuji et al. Cancer Cell. .

Abstract

In this issue of Cancer Cell, Anadon et al. perform a multi-omics analysis of ovarian tumor infiltrating tissue-resident memory T (TRM) cells at the single-cell level that supports a differentiation model from CD103-TCF1+ re-circulating T-cell precursors driven by tumor antigen recognition. CD103+ TRM cells play a dominant anti-tumor role in ovarian cancer.

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Conflict of interest statement

Declaration of interests K.O. is a co-founder of Tactiva Therapeutics and receives research support from AstraZeneca and Tesaro. T.T. and J.M. declare no competing interests.

Figures

Figure 1.
Figure 1.. Generation and differentiation of tumor-antigen specific tissue-resident CD8+ T (TRM) cells in the tumor microenvironment.
Tumor antigen-specific T cells that are primed by dendritic cells (DCs) in lymphoid tissues are recruited to ovarian tumor sites and differentiate to TCF1lowCD103+CD69+ tissue-resident memory (TRM)-like T stem (TRMstem) cells. TRMstem cells are retained in the tumor epithelial region and further differentiate to effector, proliferative and exhausted TRM subsets. CXCL16, which is expressed by multiple cell subsets in the ovarian tumor microenvironment, is considered to play a critical role in ovarian tumor tissue retention and longevity of CXCR6+ TRM cells.
See this image and copyright information in PMC

Comment on

  • Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells.
    Anadon CM, Yu X, Hänggi K, Biswas S, Chaurio RA, Martin A, Payne KK, Mandal G, Innamarato P, Harro CM, Mine JA, Sprenger KB, Cortina C, Powers JJ, Costich TL, Perez BA, Gatenbee CD, Prabhakaran S, Marchion D, Heemskerk MHM, Curiel TJ, Anderson AR, Wenham RM, Rodriguez PC, Conejo-Garcia JR. Anadon CM, et al. Cancer Cell. 2022 May 9;40(5):545-557.e13. doi: 10.1016/j.ccell.2022.03.008. Epub 2022 Apr 14. Cancer Cell. 2022. PMID: 35427494 Free PMC article.

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