Genetically proxied ketohexokinase function and risk of colorectal cancer: a Mendelian randomisation study

Amée M Buziau^{1

2

3}, Philip J Law⁴, Gabriella Blokland⁵, Casper Schalkwijk^{2

3}, Jean Scheijen^{2

3}, Pomme Simons^{1

2

3}, Carla van der Kallen^{2

6}, Simone Eussen^{2

7

8}, Pieter C Dagnelie^{2

6}, Marleen van Greevenbroek^{2

3}, Richard S Houlston⁴, Anke Wesselius^{9

10}, Molly Went⁴, Coen Stehouwer^{2

6}, Martijn Cgj Brouwers^{11

2}

Affiliations

¹ Department of Internal Medicine, division of Endocrinology and Metabolic Disease, Maastricht University Medical Centre, Maastricht, The Netherlands.
² CARIM School for Cardiovascular disease, Maastricht University, Maastricht, The Netherlands.
³ Department of Internal Medicine, Division of General Internal Medicine, Laboratory for Metabolism and Vascular Medicine, Maastricht University, Maastricht, The Netherlands.
⁴ Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
⁵ Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.
⁶ Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.
⁷ Department of Epidemiology, Maastricht University, Maastricht, The Netherlands.
⁸ CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands.
⁹ NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
¹⁰ Department of Complex Genetics and Epidemiology, Maastricht University, Maastricht, The Netherlands.
¹¹ Department of Internal Medicine, division of Endocrinology and Metabolic Disease, Maastricht University Medical Centre, Maastricht, The Netherlands mcgj.brouwers@mumc.nl.

Comment

Amée M Buziau et al. Gut. 2023 Mar.

. 2023 Mar;72(3):604-606.

doi: 10.1136/gutjnl-2021-326299. Epub 2022 May 10.

¹ Department of Internal Medicine, division of Endocrinology and Metabolic Disease, Maastricht University Medical Centre, Maastricht, The Netherlands.
² CARIM School for Cardiovascular disease, Maastricht University, Maastricht, The Netherlands.
³ Department of Internal Medicine, Division of General Internal Medicine, Laboratory for Metabolism and Vascular Medicine, Maastricht University, Maastricht, The Netherlands.
⁴ Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
⁵ Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.
⁶ Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.
⁷ Department of Epidemiology, Maastricht University, Maastricht, The Netherlands.
⁸ CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands.
⁹ NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
¹⁰ Department of Complex Genetics and Epidemiology, Maastricht University, Maastricht, The Netherlands.
¹¹ Department of Internal Medicine, division of Endocrinology and Metabolic Disease, Maastricht University Medical Centre, Maastricht, The Netherlands mcgj.brouwers@mumc.nl.

No abstract available

Keywords: COLORECTAL CANCER; GENETIC POLYMORPHISMS; NUTRITION.

Conflict of interest statement

Competing interests: None declared.

Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women.
Hur J, Otegbeye E, Joh HK, Nimptsch K, Ng K, Ogino S, Meyerhardt JA, Chan AT, Willett WC, Wu K, Giovannucci E, Cao Y. Hur J, et al. Gut. 2021 Dec;70(12):2330-2336. doi: 10.1136/gutjnl-2020-323450. Epub 2021 May 6. Gut. 2021. PMID: 33958435 Free PMC article.