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Comment
. 2022 Jun;43(6):420-422.
doi: 10.1016/j.it.2022.04.005. Epub 2022 May 8.

Inflammatory comorbidities: to train or not to train?

Suhas Bobba  1 , Shabaana A Khader  2
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Inflammatory comorbidities: to train or not to train?

Suhas Bobba et al. Trends Immunol. 2022 Jun.

Abstract

Inflammatory stimuli reprogram innate immune cells to generate rigorous responses to future challenge with heterologous stimuli through trained immunity. Li et al. show that training of hematopoietic stem cells (HSCs) in the bone marrow primes cells to generate more inflammatory myeloid progeny and, thereby, mechanistically links inflammatory comorbidities.

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Declaration of interests No interests are declared.

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