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. 2022 Jun;28(6):439-442.
doi: 10.1016/j.molmed.2022.04.004. Epub 2022 May 7.

Combinatorial therapies for rescuing myotonic dystrophy type 1 skeletal muscle defects

Aymeric Ravel-Chapuis  1 , Bernard J Jasmin  2
Affiliations

Combinatorial therapies for rescuing myotonic dystrophy type 1 skeletal muscle defects

Aymeric Ravel-Chapuis et al. Trends Mol Med. 2022 Jun.

Abstract

Myotonic dystrophy type 1 (DM1) is a multisystemic disorder for which there is no cure. In recent years, progress has been made in defining disease mechanisms and in developing novel therapies, especially for skeletal muscle defects. Here, we highlight the potential of activating AMP-activated protein kinase (AMPK) with different approaches in combinatorial therapies.

Keywords: AMP-activated protein kinase; combinatorial therapy; exercise; myotonic dystrophy; skeletal muscle.

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