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Case Reports
. 2022 May;52(5):872-875.
doi: 10.1111/imj.15781.

Enzyme replacement therapy leading to improvement in myeloma indices in a patient with concomitant Gaucher disease

Reut Harel #  1 , Israel Gavish #  1 , Ariel Aviv  1 , Nofar Greenman Maravi  2 , Philippe Trougouboff  2 , Ari Zimran  3   4 , Shoshana Revel-Vilk  3   4
Affiliations
Case Reports

Enzyme replacement therapy leading to improvement in myeloma indices in a patient with concomitant Gaucher disease

Reut Harel et al. Intern Med J. 2022 May.

Abstract

Patients with Gaucher disease (GD) have been shown previously to carry an increased risk for cancer, most commonly multiple myeloma (MM). It is currently unknown whether treatment for GD has an effect on the prevention or amelioration of MM. We present the case of a 41-year-old patient simultaneously diagnosed with GD and smouldering MM. Enzyme replacement therapy with Velaglucerase-alfa significantly improved myeloma indices.

Keywords: Gaucher disease; enzyme replacement therapy; monoclonal gammopathy of unknown significance (MGUS); multiple myeloma; polyclonal gammopathy.

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References

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