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Comment
. 2022 Jun;600(11):2815.
doi: 10.1113/JP283189. Epub 2022 May 10.

Reply from George A. Brooks

George A Brooks  1
Affiliations
Comment

Reply from George A. Brooks

George A Brooks. J Physiol. 2022 Jun.
No abstract available

Keywords: cardiac muscle; gluconeogenesis; lactate and brain; lactate shuttle; lactate signalling; lactylation; olfr78; oxidative metabolism.

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Comment on

  • Lactate in contemporary biology: a phoenix risen.
    Brooks GA, Arevalo JA, Osmond AD, Leija RG, Curl CC, Tovar AP. Brooks GA, et al. J Physiol. 2022 Mar;600(5):1229-1251. doi: 10.1113/JP280955. Epub 2021 Feb 25. J Physiol. 2022. PMID: 33566386 Free PMC article.
  • How high can the lactate phoenix rise?
    Langan SP, Navarro JS. Langan SP, et al. J Physiol. 2022 Jun;600(11):2813-2814. doi: 10.1113/JP283089. Epub 2022 May 10. J Physiol. 2022. PMID: 35538348 No abstract available.

References

    1. Brooks, G. A. (1985). Lactate: Glycolytic end product and oxidative substrate during sustained exercise in mammals – the “lactate shuttle”. In: R. Gilles (Ed.). Circulation, Respiration, and Metabolism. Proceedings in Life Sciences. Berlin, Heidelberg: Springer, 208–218.
    1. Brooks, G. A. (2002). Lactate shuttles in nature. Biochemical Society Transactions, 30(2), 258–264. - PubMed
    1. Brooks, G. A. , Arevalo, J. A. , Osmond, A. D. , Leija, R. G. , Curl, C. C. , & Tovar, A. P. (2022). Lactate in contemporary biology: A phoenix risen. Journal of Physiology, 600(5), 1229–1251. - PMC - PubMed
    1. Chang, A. J. , Ortega, F. E. , Riegler, J. , Madison, D. V. , & Krasnow, M. A. (2015). Oxygen regulation of breathing through an olfactory receptor activated by lactate. Nature, 527(7577), 240–244. - PMC - PubMed
    1. Hashimoto, T. , Hussien, R. , Oommen, S. , Gohil, K. , & Brooks, G. A. (2007). Lactate sensitive transcription factor network in L6 cells: Activation of MCT1 and mitochondrial biogenesis. FASEB Journal, 21(10), 2602–2612. - PubMed