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Review
. 2022 May 10;22(1):159.
doi: 10.1186/s12893-022-01613-z.

Clinicopathological study of gastric schwannoma and review of related literature

Zhihan Zhong #  1 , Yuhao Xu #  1 , Junwei Liu  2 , Chengwu Zhang  2 , Zunqiang Xiao  2 , Yan Xia  3 , Yu Wang  4 , Jianfeng Wang  5 , Qiuran Xu  6 , Yi Lu  7
Affiliations
Review

Clinicopathological study of gastric schwannoma and review of related literature

Zhihan Zhong et al. BMC Surg. .

Abstract

Background: This study aimed to investigate the clinical features, diagnostic criteria, treatment options, and prognosis of patients with gastric schwannoma (GS).

Methods: We collected the clinical data of all patients pathologically diagnosed with GS in Zhejiang Provincial People's Hospital from May 2012 to October 2021.

Results: A total of 26 cases of GS were analyzed clinicopathologically, where the sizes of the tumor were found to be in the range of 1-6 cm (mean: 3.16 cm, median: 3.05 cm). A computed tomography (CT) scan analysis revealed that most masses were either moderately progressive or uniformly enhanced. According to ultrasound gastroscopy results, most of them were hypoechoic masses. There were 23 cases of surgery and three cases of endoscopic submucosal tumor dissection. Immunohistochemistry demonstrated that S100 was positive in 26 patients, immunomarker SOX10 was positive in five, whereas CD34, CD117, and SMA were negative in most patients. CK (Pan), Dog-1, and Desmin were also found negative. All 26 cases were followed up after the conclusion of the study where no evidence of recurrence or metastasis was observed.

Conclusions: GS is a unique form of peripheral schwannoma. The diagnosis of this type of tumor depends on the pathology and immunohistochemistry of the individual. The key to treating this type of tumor is endoscopy and surgery. Follow up and related literature review showed that GS was a benign tumor with little possibility of malignant transformation.

Keywords: Prognosis; S100 protein; Schwannoma; Stomach.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
The gross appearance of a case of gastric schwannoma. The surface of the specimen section is grayish yellow
Fig. 2
Fig. 2
Enhanced CT images of four cases of gastric schwannoma
Fig. 3
Fig. 3
Ultrasonographic gastroscopic images of four cases of gastric schwannoma. Obvious ulcer can be seen on the surface of the mass in the upper two pictures
Fig. 4
Fig. 4
HE piceure of four cases of gastric schwannoma,all of which were spindle cells(All pictures have 10 × 10 magnification)
Fig. 5
Fig. 5
Figure a shows S-100 strong positive; Figure b shows S-100 positive; Figure c shows Sox positive; Figure d shows CD117 negative (All pictures have 10 × 10 magnification)
Fig. 6
Fig. 6
A shows Desmin1 negative; Figure b shows SMA negative; Figure c shows DOG1 negative; Figure d shows CD34 negative (All pictures have 10 × 10 magnification)
See this image and copyright information in PMC

References

    1. Daimaru Y, Kido H, Hashimoto H, Enjoji M. Benign schwannoma of the gastrointestinal tract: a clinicopathologic and immunohistochemical study. Hum Pathol. 1988;19(3):257–264. doi: 10.1016/S0046-8177(88)80518-5. - DOI - PubMed
    1. Sreevathsa MR, Pipara G. Gastric schwannoma. A case report and review of literature. Indian J Surg Oncol. 2015;6(2):123–126. doi: 10.1007/s13193-014-0367-7. - DOI - PMC - PubMed
    1. Lu ZY, Zhao DY. Gastric schwannoma treated by endoscopic full-thickness resection and endoscopic purse-string suture: a case report. World J Gastroenterol. 2021;27(25):3940–3947. doi: 10.3748/wjg.v27.i25.3940. - DOI - PMC - PubMed
    1. Mohamad MA, Jarmin R, Md Pauzi SH. Gastric schwannoma in an elderly man: a case report. Malays J Pathol. 2020;42(3):455–459. - PubMed
    1. Voltaggio L, Murray R, Lasota J, Miettinen M. Gastric schwannoma: a clinicopathologic study of 51 cases and critical review of the literature. Hum Pathol. 2012;43(5):650–659. doi: 10.1016/j.humpath.2011.07.006. - DOI - PMC - PubMed