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. 2018 Feb 19;8(14):7832-7838.
doi: 10.1039/c8ra00291f. eCollection 2018 Feb 14.

Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis

Yin Nian  1 , Ni-Hong Lu  2 , Xiao-Ling Liu  1 , Da-Shan Li  1 , Lin Zhou  1 , Ming-Hua Qiu  1
Affiliations

Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis

Yin Nian et al. RSC Adv. .

Abstract

Two new cycloartane triterpenes, cimyunnin E (1), containing a unique oxaspiro[4.4]nonanedione moiety based on rings D and E, together with cimicifine B (2), a 25,26,27-trinortriterpene featuring a pyridine ring E, were purified from the fruits of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic methods and ECD (electronic circular dichroism calculations). Compounds 1 and 2 showed significant acetylcholinesterase (AChE) inhibition with IC50 values of 1.58 and 3.87 μM, respectively. In addition, they noticeably enhanced the neurite outgrowth of nerve growth factor (NGF) mediated PC12 cells at a concentration of 10 μM.

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Conflict of interest statement

There are no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1. Structures of compounds 1 and 2.
Fig. 2
Fig. 2. Major HMBC (), 1H–1H COSY (), and ROESY () correlations of compound 1.
Fig. 3
Fig. 3. The Newman projection of C-23/C-24 coupling system of 1.
Fig. 4
Fig. 4. Calculated ECD spectra for -(17S,20R,23R,24S)-1 (red dashed line) and -(17R,20S,23S,24R)-1 (blue dashed line). Experimental CD spectrum of 1 (black solid line).
Fig. 5
Fig. 5. Major HMBC (), 1H–1H COSY (), and ROESY () correlations of compound 2.
See this image and copyright information in PMC

References

    1. Liske E. Wustenberg P. Menopause. 1998;5:250–255. doi: 10.1097/00042192-199805040-00051. - DOI
    1. McKenna D. J. Jones K. Humphrey S. Hughes K. Altern. Ther. 2001;7:93–100. - PubMed
    1. Nobuko S. Mutsuo K. Harukuni T. Teruo M. Fumio E. Hoyoku N. Masahiro N. Yohiro S. Kuo H. L. Bioorg. Med. Chem. 2005;13:1403–1408. doi: 10.1016/j.bmc.2004.10.062. - DOI - PubMed
    1. Chinese Pharmacopoeia Commission, The Pharmacopoeia of Chinese People's Republic, ed. Y. Li, The Chemical Industry Publishing House, Beijing, China, 2010, vol. 1, pp. 68–69
    1. Nian Y. Zhu H. Tang W. R. Luo Y. Du J. Qiu M. H. J. Nat. Prod. 2013;76:896–902. doi: 10.1021/np4000262. - DOI - PubMed