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. 1987;326(6116):846-52.
doi: 10.1038/326846a0.

Structure of the repressor-operator complex of bacteriophage 434

J E Anderson, M Ptashne, S C Harrison

Structure of the repressor-operator complex of bacteriophage 434

J E Anderson et al. Nature. 1987.

Abstract

The crystal structure of a specific complex between the DNA-binding domain of phage 434 repressor and a synthetic 434 operator DNA shows interactions that determine sequence-dependent affinity. The repressor recognizes its operators by its complementarity to a particular DNA conformation as well as by direct interaction with base pairs in the major groove.

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