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Review
. 2022 May 2:40:95-103.
doi: 10.1016/j.euros.2022.04.001. eCollection 2022 Jun.

Diagnostic Performance of a Magnetic Resonance Imaging-directed Targeted plus Regional Biopsy Approach in Prostate Cancer Diagnosis: A Systematic Review and Meta-analysis

Marinus J Hagens  1   2   3 , Mar Fernandez Salamanca  4   5 , Anwar R Padhani  6 , Pim J van Leeuwen  2   3 , Henk G van der Poel  1   2   3 , Ivo G Schoots  4   7
Affiliations
Review

Diagnostic Performance of a Magnetic Resonance Imaging-directed Targeted plus Regional Biopsy Approach in Prostate Cancer Diagnosis: A Systematic Review and Meta-analysis

Marinus J Hagens et al. Eur Urol Open Sci. .

Abstract

Context: Systematic biopsies are additionally recommended to maximize the diagnostic performance of the magnetic resonance imaging (MRI) diagnostic pathway for men with suspected prostate cancer (PCa) and positive scans. To reduce unnecessary systematic biopsies (SBx), MRI-directed approaches comprising targeted plus regional biopsy (TBx + RBx) are being investigated.

Objective: To systematically evaluate the diagnostic performance of MRI-directed TBx + RBx approaches in comparison to MRI-directed TBx alone and TBx + SBx approaches.

Evidence acquisition: The MEDLINE and Embase databases were searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses process. Identified reports were critically appraised according to the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) criteria. Detection of grade group (GG) ≥2 PCa was the endpoint of interest. Fixed-effect meta-analyses were conducted to characterize summary effect sizes and quantify heterogeneity. Only MRI-positive men were included.

Evidence synthesis: A total of eight studies were included for analysis. Among a cumulative total of 2603 men with suspected PCa, the GG ≥2 PCa detection rate did not significantly differ between MRI-directed TBx + RBx and TBx + SBx approaches (risk ratio [RR] 0.95, 95% confidence interval [CI] 0.90-1.01; p = 0.09). The TBx + RBx results were obtained using significantly fewer biopsy cores and avoiding contralateral SBx altogether. By contrast, there was significant difference in GG ≥2 PCa detection between MRI-directed TBx + RBx and TBx approaches (RR 1.18, 95% CI 1.10-1.25; p < 0.001).

Conclusions: MRI-directed TBx + RBx approaches showed a nonsignificant difference in detection of GG ≥2 PCa compared to the recommended practice of MRI-directed TBx + SBx. However, owing to the extensive heterogeneity among the studies included, future prospective clinical studies are needed to further investigate, optimize, and standardize this promising biopsy approach.

Patient summary: We reviewed the scientific literature on prostate biopsy approaches using magnetic resonance imaging (MRI)-directed targeted biopsy plus regional biopsy of the prostate. The studies we identified found arguments to potentially embrace such a combined biopsy approach for future diagnostics in prostate cancer.

Keywords: Diagnostic accuracy; Prostate biopsy; Prostate cancer; Regional biopsies; Systematic biopsies.

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Figures

Fig. 1
Fig. 1
Definition of an MRI-directed targeted plus regional biopsy (TBx + RBx) approach: TBx with additional perilesional, ipsilateral, or sector biopsies. MRI = magnetic resonance imaging.
Fig. 2
Fig. 2
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram showing the search outcome and selection of full studies included in the review , , , , , , , and the studies excluded , , .
Fig. 3
Fig. 3
Forest plots for the detection rate of (A) targeted plus regional biopsies (TBx + RBx) in comparison to targeted plus systematic biopsies (TBx + SBx) and (B) TBx + SBx in comparison to targeted-only biopsy (TBx). (C) Forrest plot for the detection rate of TBx + RBx in comparison to TBx. CI = confidence interval; df = degrees of freedom; M-H = Mantel-Haenszel.
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