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Case Reports
. 2022 May 5;10(5):e05829.
doi: 10.1002/ccr3.5829. eCollection 2022 May.

No child should suffer from vitamin K deficiency-induced bleeding disorders

Masazumi Miyahara  1 , Kyoko Osaki  1
Affiliations
Case Reports

No child should suffer from vitamin K deficiency-induced bleeding disorders

Masazumi Miyahara et al. Clin Case Rep. .

Abstract

We encountered an 11-day-old male neonate with vitamin K deficiency-induced intracranial hemorrhage, despite receiving oral vitamin K2 (menaquinone-4) prophylaxis according to Japanese guidelines. This case suggests that the current vitamin K deficiency-bleeding prophylaxis programs cannot prevent bleeding completely. Better prophylaxis programs using both intramuscular and oral administration should be considered.

Keywords: intracranial hemorrhage; prophylaxis; vitamin K deficiency bleeding.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Brain computed tomography shows intracranial hemorrhage in the left ventricle and the surrounding parenchyma
See this image and copyright information in PMC

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References

    1. Loughnan PM, McDougall PN. Epidemiology of late onset haemorrhagic disease: a pooled data analysis. J Paediatr Child Health. 1993;29(3):177‐181. doi:10.1111/j.1440-1754.1993.tb00480.x - DOI - PubMed
    1. Araki S, Shirahata A. Vitamin K deficiency bleeding in infancy. Nutrients. 2020;12(3):780. doi:10.3390/nu12030780 - DOI - PMC - PubMed
    1. Takahashi D, Shirahata A, Itoh S, Takahashi Y, Nishiguchi T, Matsuda Y. Vitamin K prophylaxis and late vitamin K deficiency bleeding in infants: fifth nationwide survey in Japan. Pediatr Int. 2011;53(6):897‐901. doi:10.1111/j.1442-200X.2011.03392.x - DOI - PubMed
    1. von Kries R, Shearer MJ, Göbel U. Vitamin K in infancy. Eur J Pediatr. 1988;147(2):106‐112. doi:10.1007/BF00442204 - DOI - PubMed
    1. Golding J, Greenwood R, Birmingham K, Mott M. Childhood cancer, intramuscular vitamin K, and pethidine given during labour. BMJ. 1992;305(6849):341‐346. doi:10.1136/bmj.305.6849.341 - DOI - PMC - PubMed

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