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. 2018 Mar 7;8(18):9718-9722.
doi: 10.1039/c8ra00659h. eCollection 2018 Mar 5.

Convenient and efficient synthesis of functionalized unsymmetrical Z-alkenyl disulfanes

M Musiejuk  1 , J Doroszuk  1 , D Witt  1
Affiliations

Convenient and efficient synthesis of functionalized unsymmetrical Z-alkenyl disulfanes

M Musiejuk et al. RSC Adv. .

Abstract

We developed a simple and efficient method for the synthesis of functionalized unsymmetrical Z-alkenyl disulfanes under mild conditions in moderate to good yields. The designed method is based on the reaction of Z-alkenyl thiotosylates with thiols in the presence of base. The developed method allows the preparation of unsymmetrical Z-alkenyl disulfanes bearing additional hydroxy, carboxy, or amino functionalities.

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Conflict of interest statement

There are no conflicts to declare.

Figures

Scheme 1
Scheme 1. Preparation of Z-1-octenyl p-toluenethiosulfonate 4.
See this image and copyright information in PMC

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