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. 1987 May;84(9):3014-8.
doi: 10.1073/pnas.84.9.3014.

Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmodium falciparum malaria

W A Siddiqui, L Q Tam, K J Kramer, G S Hui, S E Case, K M Yamaga, S P Chang, E B Chan, S C Kan

Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmodium falciparum malaria

W A Siddiqui et al. Proc Natl Acad Sci U S A. 1987 May.

Abstract

Groups of Aotus (owl) monkeys were immunized with either the Plasmodium falciparum merozoite surface-coat precursor protein and its processing fragments or a complex of high molecular mass rhoptry proteins and challenged with a lethal infection of the homologous P. falciparum Uganda Palo Alto (FUP) strain. No patent parasitemia could be detected on thick blood films of monkeys immunized with the merozoite surface antigens; however, only one of three monkeys immunized with the rhoptry proteins was partially protected, while two required drug therapy. The experiment clearly demonstrates that the merozoite surface-coat precursor protein can completely protect Aotus monkeys against a lethal infection of the human malaria parasite.

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