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Review
. 2022 Sep;46(9):e14230.
doi: 10.1111/jfbc.14230. Epub 2022 May 11.

Baicalein: A review on its anti-cancer effects and mechanisms in lung carcinoma

Naveenkumar Chandrashekar  1 , Anandakumar Pandi  2
Affiliations
Review

Baicalein: A review on its anti-cancer effects and mechanisms in lung carcinoma

Naveenkumar Chandrashekar et al. J Food Biochem. 2022 Sep.

Abstract

Plant-derived flavonoids are reported to function as potential anti-cancer agents against different types of cancer. Baicalein (BE) is an important flavonoid found in the roots of Scutellaria baicalensis that is popularly used in Chinese medicine as an ingredient in herbal tea preparations to promote wellness. BE has been studied for its several biological effects including antioxidant, anti-inflammatory, anti-hepatotoxic, antiviral, and anti-tumor properties. BE has now been discovered to be an effective agent against lung neoplasm. The molecular factors supporting baicalein's anti-cancer activity against lung cancer and its value to human health are discussed in this article. This would help in identifying BE as a promising competent drug against lung carcinoma. PRACTICAL APPLICATIONS: Baicalein is a flavonoid obtained from the roots of Scutellaria baicalensis. It has been widely used as an antioxidant, anti-inflam5matory, anti-hepatotoxic, antiviral, and anti-cancer agent. Lung cancer is one of the most common malignancies in the world with a high fatality rate. Several studies have found that Baicalein is an important candidate for treating lung cancer. Its mechanism of action includes regulation of cell proliferation, metastasis, apoptosis, autophagy, and so on. Baicalein could be used as a novel anti-cancer drug for the treatment of lung carcinoma.

Keywords: apoptosis; baicalein; cell cycle arrest; in vitro; in vivo; lung cancer.

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