Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study

Hiba Fatayer¹, Rachel L O'Connell², Finian Bannon³, Charlotte E Coles⁴, Ellen Copson⁵, Ramsey I Cutress⁵, Rajiv V Dave⁶, Matthew D Gardiner^{7

8}, Margaret Grayson⁹, Christopher Holcombe¹, Sheeba Irshad^{10

11}, Gareth W Irwin¹², Ciara O'Brien^{13

14}, Carlo Palmieri^{15

16}, Abeer M Shaaban¹⁷, Nisha Sharma¹⁸, Jagdeep K Singh¹⁹, Ian Whitehead¹, Shelley Potter^{20

21}, Stuart A McIntosh²²; NeST Study Research Collaborative

Collaborators, Affiliations

Collaborators

NeST Study Research Collaborative:
H Curry, E Iddles, M Mahmood, Y Masannat, J Schneider, L Simpson, M Sidapra, L Baker, H Capitelli-McMahon, M Hughes, A Isaac, B Skelly, C Sirianni, N Hirst, R Linforth, A Botes, T Robinson, T Schrire, J Alfred, H Lennon, D Dumitru, E Kleidi, F Hoar, E MacInnes, K Sharma, T Alaguthurai, N Chand, C A Farulla, A Hayward, B Pearce, M Tatterton, S Laws, J Iqbal, M S Mirza, K V Sainarayanan, L Humphreys, S Tayeh, S Jones, A Ansari, R Bate, B C J Wei, B Gurung, F M T Leone, C Mitchell, G Mondani, S Pilgrim, T Sun, G Boundouki, R Broadbent, A Khan, F Morgans-Slader, J Rai, R Soulsby, H Cain, R Thomas, B Elsberger, G Walls, S Cadwell-Sneath, J Couch, M D'Auria, C Grundy, S Hitchin, H Khout, F Latief, J Mondani, A Nessa, G Oni, L Sawers, S S Rajan, Q Tan, L Whisker, A Ghoneima, M Rezacova, N Marikakis, L Ballance, U Andaleeb, N Basu, T Hubbard, A Maxwell, M Roland, C Weerasinghe, Q Ain, G Bitsakou, C Chamberlain, N Chopra, A Micha, C Norman, P Padmanabhan, N Patani, K Shanthakunalan, E St John, S Jafferbhoy, C Bransgrove, A Hussein, J Livingstone, O Waker, J Hack, S Hadad, J Newell, A Heetun, A Hargreaves, E Rahman, R Vidya

Affiliations

¹ Liverpool Breast Unit, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
² Department of Breast Surgery, Royal Marsden NHS Foundation Trust, Sutton, UK.
³ Centre for Public Health, Queen's University Belfast, Institute of Clinical Science, Belfast, UK.
⁴ Department of Oncology, University of Cambridge, Cambridge, UK.
⁵ Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton and University Hospital Southampton, Southampton, UK.
⁶ Nightingale Breast Cancer Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
⁷ Department of Plastic Surgery, Wexham Park Hospital, Frimley Health NHS Foundation Trust, Slough, UK.
⁸ Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
⁹ Northern Ireland Cancer Research Consumer Forum, Northern Ireland Cancer Trials Network, Belfast City Hospital, Belfast, UK.
¹⁰ Guy's Cancer Centre, Guy's and St Thomas' NHS Trust, London, UK.
¹¹ School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
¹² Breast Surgery Department, Belfast City Hospital, Belfast Health and Social Care Trust, Belfast, UK.
¹³ Department of Medical Oncology, Christie Hospital NHS Foundation Trust, Manchester, UK.
¹⁴ School of Medical Sciences Faculty of Biology, Medicine and Health University of Manchester, Manchester, UK.
¹⁵ University of Liverpool, Institute of Systems, Molecular and Integrative Biology, Department of Molecular and Clinical Cancer Medicine, Liverpool, UK.
¹⁶ Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK.
¹⁷ Department of Pathology, Queen Elizabeth Hospital Birmingham and University of Birmingham, Birmingham, UK.
¹⁸ Breast Unit, St James's Hospital, Leeds, UK.
¹⁹ Surrey and Sussex Healthcare NHS Trust, East Surrey Hospital, Redhill, UK.
²⁰ Bristol Centre for Surgical Research, Population Health Sciences, Bristol Medical School, Bristol, UK.
²¹ Bristol Breast Care Centre, North Bristol NHS Trust, Southmead Hospital, Bristol, UK.
²² Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.

PMID: 35543289
PMCID: PMC10364769
DOI: 10.1093/bjs/znac131

Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study

Hiba Fatayer et al. Br J Surg. 2022.

. 2022 Aug 16;109(9):800-803.

doi: 10.1093/bjs/znac131.

Authors

Collaborators

NeST Study Research Collaborative:
H Curry, E Iddles, M Mahmood, Y Masannat, J Schneider, L Simpson, M Sidapra, L Baker, H Capitelli-McMahon, M Hughes, A Isaac, B Skelly, C Sirianni, N Hirst, R Linforth, A Botes, T Robinson, T Schrire, J Alfred, H Lennon, D Dumitru, E Kleidi, F Hoar, E MacInnes, K Sharma, T Alaguthurai, N Chand, C A Farulla, A Hayward, B Pearce, M Tatterton, S Laws, J Iqbal, M S Mirza, K V Sainarayanan, L Humphreys, S Tayeh, S Jones, A Ansari, R Bate, B C J Wei, B Gurung, F M T Leone, C Mitchell, G Mondani, S Pilgrim, T Sun, G Boundouki, R Broadbent, A Khan, F Morgans-Slader, J Rai, R Soulsby, H Cain, R Thomas, B Elsberger, G Walls, S Cadwell-Sneath, J Couch, M D'Auria, C Grundy, S Hitchin, H Khout, F Latief, J Mondani, A Nessa, G Oni, L Sawers, S S Rajan, Q Tan, L Whisker, A Ghoneima, M Rezacova, N Marikakis, L Ballance, U Andaleeb, N Basu, T Hubbard, A Maxwell, M Roland, C Weerasinghe, Q Ain, G Bitsakou, C Chamberlain, N Chopra, A Micha, C Norman, P Padmanabhan, N Patani, K Shanthakunalan, E St John, S Jafferbhoy, C Bransgrove, A Hussein, J Livingstone, O Waker, J Hack, S Hadad, J Newell, A Heetun, A Hargreaves, E Rahman, R Vidya

Affiliations

¹ Liverpool Breast Unit, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
² Department of Breast Surgery, Royal Marsden NHS Foundation Trust, Sutton, UK.
³ Centre for Public Health, Queen's University Belfast, Institute of Clinical Science, Belfast, UK.
⁴ Department of Oncology, University of Cambridge, Cambridge, UK.
⁵ Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton and University Hospital Southampton, Southampton, UK.
⁶ Nightingale Breast Cancer Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
⁷ Department of Plastic Surgery, Wexham Park Hospital, Frimley Health NHS Foundation Trust, Slough, UK.
⁸ Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
⁹ Northern Ireland Cancer Research Consumer Forum, Northern Ireland Cancer Trials Network, Belfast City Hospital, Belfast, UK.
¹⁰ Guy's Cancer Centre, Guy's and St Thomas' NHS Trust, London, UK.
¹¹ School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
¹² Breast Surgery Department, Belfast City Hospital, Belfast Health and Social Care Trust, Belfast, UK.
¹³ Department of Medical Oncology, Christie Hospital NHS Foundation Trust, Manchester, UK.
¹⁴ School of Medical Sciences Faculty of Biology, Medicine and Health University of Manchester, Manchester, UK.
¹⁵ University of Liverpool, Institute of Systems, Molecular and Integrative Biology, Department of Molecular and Clinical Cancer Medicine, Liverpool, UK.
¹⁶ Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK.
¹⁷ Department of Pathology, Queen Elizabeth Hospital Birmingham and University of Birmingham, Birmingham, UK.
¹⁸ Breast Unit, St James's Hospital, Leeds, UK.
¹⁹ Surrey and Sussex Healthcare NHS Trust, East Surrey Hospital, Redhill, UK.
²⁰ Bristol Centre for Surgical Research, Population Health Sciences, Bristol Medical School, Bristol, UK.
²¹ Bristol Breast Care Centre, North Bristol NHS Trust, Southmead Hospital, Bristol, UK.
²² Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.

PMID: 35543289
PMCID: PMC10364769
DOI: 10.1093/bjs/znac131

Erratum in

Corrigendum to: Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study.
Fatayer H, O'Connell RL, Bannon F, Coles CE, Copson E, Cutress RI, Dave RV, Gardiner MD, Grayson M, Holcombe C, Irshad S, Irwin GW, O'Brien C, Palmieri C, Shaaban AM, Sharma N, Singh JK, Whitehead I, Potter S, McIntosh SA; NeST Study Research Collaborative. Fatayer H, et al. Br J Surg. 2022 Dec 13;110(1):124. doi: 10.1093/bjs/znac282. Br J Surg. 2022. PMID: 36075875 Free PMC article. No abstract available.

No abstract available

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Figures

**Fig. 1**
Surgical management, showing surgical plan at diagnosis and actual surgical management after systemic therapy MDT, multidisciplinary team; NACT, neoadjuvant chemotherapy; IBR, immediate breast reconstruction; BCS, breast-conserving surgery.

See this image and copyright information in PMC

References

1. Makris A, Powles T, Ashley S, Chang J, Hickish T, Tidy V et al. A reduction in the requirements for mastectomy in a randomized trial of neoadjuvant chemoendocrine therapy in primary breast cancer. Ann Oncol 1998;9:1179. - PubMed
1. Kuerer HM, Hunt KK, Newman LA, Ross MI, Ames FC, Singletary SE. Neoadjuvant chemotherapy in women with invasive breast carcinoma: conceptual basis and fundamental surgical issues. J Am Coll Surg 2000;190:350–363 - PubMed
1. Boughey JC, Suman VJ, Mittendorf EA, Ahrendt GM, Wilke LG, Taback B et al. Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial. JAMA 2013;310:1455–1461 - PMC - PubMed
1. Symmans WF, Wei C, Gould R, Yu X, Zhang Y, Liu M et al. Long-term prognostic risk after neoadjuvant chemotherapy associated with residual cancer burden and breast cancer subtype. J Clin Oncol 2017;35:1049. - PMC - PubMed
1. Loibl S, O’Shaughnessy J, Untch M, Sikov WM, Rugo HS, McKee MD et al. Addition of the PARP inhibitor veliparib plus carboplatin or carboplatin alone to standard neoadjuvant chemotherapy in triple-negative breast cancer (BrighTNess): a randomised, phase 3 trial. Lancet Oncol 2018;19:497–509 - PubMed

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Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study

Collaborators

Affiliations

Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study

Authors

Collaborators

Affiliations

Erratum in

Figures

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical