Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Aug 1;41(8):e318-e320.
doi: 10.1097/INF.0000000000003573. Epub 2022 Jul 13.

Antibody Seronegativity in COVID-19 RT-PCR-Positive Children

Maala Bhatt  1 , Roger L Zemek  1 , Ken Tang  2 , Richard Malley  3 , Amy C Plint  1 , Anne Pham-Huy  1 , Jennifer Dawson  2 , Candice McGahern  2 , Martin Pelchat  4 , Corey Arnold  4 , Yannick Galipeau  4 , Marc-André Langlois  4
Affiliations

Antibody Seronegativity in COVID-19 RT-PCR-Positive Children

Maala Bhatt et al. Pediatr Infect Dis J. .

Abstract

This substudy of a prospective case-ascertained household transmission study investigated severe acute respiratory syndrome coronavirus 2 reverse transcription polymerase chain reaction-positive individuals without antibody development and factors associated with nonseroconversion. Approximately 1 of 8 individuals with coronavirus disease 2019 did not seroconvert. Children, particularly the youngest, were approximately half as likely to seroconvert compared with adults. Apart from the absence of fever/chills, individual symptoms did not strongly predict nonseroconversion.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

    1. Post N, Eddy D, Huntley C, et al. . Antibody response to SARS-CoV-2 infection in humans: a systematic review. PLoS One. 2020;15:e0244126. - PMC - PubMed
    1. Yang HS, Costa V, Racine-Brzostek SE, et al. . Association of age with SARS-CoV-2 antibody response. JAMA Netw Open. 2021;4:e214302. - PMC - PubMed
    1. Majdoubi A, Michalski C, O’Connell SE, et al. . A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2. JCI Insight. 2021;6:146316. - PMC - PubMed
    1. Wei J, Matthews PC, Stoesser N, et al. ; COVID-19 Infection Survey team. Anti-spike antibody response to natural SARS-CoV-2 infection in the general population. Nat Commun. 2021;12:6250. - PMC - PubMed
    1. Alshami A, Al Attas R, Anan H, et al. . Durability of antibody responses to SARS-CoV-2 infection and its relationship to disease severity assessed using a commercially available assay. Front Microbiol. 2021;12:770727. - PMC - PubMed

Publication types

Grants and funding