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Comment
. 2022 May 10;17(5):1012-1013.
doi: 10.1016/j.stemcr.2022.04.011.

SARS-CoV-2 and type I interferon signaling in brain endothelial cells: Blurring the lines between friend or foe

George D Vavougios  1 , Sotirios G Zarogiannis  2 , Georgios Hadjigeorgiou  3 , Karen A Krogfelt  4 , Konstantinos I Gourgoulianis  5
Affiliations
Comment

SARS-CoV-2 and type I interferon signaling in brain endothelial cells: Blurring the lines between friend or foe

George D Vavougios et al. Stem Cell Reports. .
No abstract available

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment in

Comment on

  • The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2.
    Krasemann S, Haferkamp U, Pfefferle S, Woo MS, Heinrich F, Schweizer M, Appelt-Menzel A, Cubukova A, Barenberg J, Leu J, Hartmann K, Thies E, Littau JL, Sepulveda-Falla D, Zhang L, Ton K, Liang Y, Matschke J, Ricklefs F, Sauvigny T, Sperhake J, Fitzek A, Gerhartl A, Brachner A, Geiger N, König EM, Bodem J, Franzenburg S, Franke A, Moese S, Müller FJ, Geisslinger G, Claussen C, Kannt A, Zaliani A, Gribbon P, Ondruschka B, Neuhaus W, Friese MA, Glatzel M, Pless O. Krasemann S, et al. Stem Cell Reports. 2022 Feb 8;17(2):307-320. doi: 10.1016/j.stemcr.2021.12.011. Epub 2022 Jan 20. Stem Cell Reports. 2022. PMID: 35063125 Free PMC article.

References

    1. Constant O., Barthelemy J., Bolloré K., Tuaillon E., Gosselet F., Chable-Bessia C., Merida P., Muriaux D., Van de Perre P., Salinas S., Simonin Y. SARS-CoV-2 Poorly replicates in cells of the Human blood-brain barrier without Associated Deleterious Effects. Front. Immunol. 2021;12 doi: 10.3389/fimmu.2021.697329. - DOI - PMC - PubMed
    1. Iadecola C., Anrather J., Kamel H. Effects of COVID-19 on the nervous system. Cell. 2020;183:16–27.e1. doi: 10.1016/j.cell.2020.08.028. e11. - DOI - PMC - PubMed
    1. Kim E.S., Jeon M.-T., Kim K.-S., Lee S., Kim S., Kim D.-G. Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the brain endothelial cells. Viruses. 2021;13:2021. doi: 10.3390/v13102021. - DOI - PMC - PubMed
    1. Kim E.S., Jeon M.T., Kim K.S., Lee S., Kim S., Kim D.G. Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the brain endothelial cells. Viruses. 2021;13 doi: 10.3390/v13102021. - DOI - PMC - PubMed
    1. Krasemann S., Haferkamp U., Pfefferle S., Woo M.S., Heinrich F., Schweizer M., Appelt-Menzel A., Cubukova A., Barenberg J., Leu J., et al. The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2. Stem Cell Rep. 2022;17:307–320. doi: 10.1016/j.stemcr.2021.12.011. - DOI - PMC - PubMed

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