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Comment
. 2022 May 10;55(5):735-737.
doi: 10.1016/j.immuni.2022.04.014.

KIRs mark killers suppressing autoimmunity

June-Young Koh  1 , Eui-Cheol Shin  2
Affiliations
Free article
Comment

KIRs mark killers suppressing autoimmunity

June-Young Koh et al. Immunity. .
Free article

Abstract

Identification of regulatory CD8+ T cells that suppress pathological immune responses is an importunate pursuit. In a recent issue of Science, Li et al. demonstrated that human KIR+CD8+ T cells suppress autoimmunity by eliminating pathogenic CD4+ T cells.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19.
    Li J, Zaslavsky M, Su Y, Guo J, Sikora MJ, van Unen V, Christophersen A, Chiou SH, Chen L, Li J, Ji X, Wilhelmy J, McSween AM, Palanski BA, Mallajosyula VVA, Bracey NA, Dhondalay GKR, Bhamidipati K, Pai J, Kipp LB, Dunn JE, Hauser SL, Oksenberg JR, Satpathy AT, Robinson WH, Dekker CL, Steinmetz LM, Khosla C, Utz PJ, Sollid LM, Chien YH, Heath JR, Fernandez-Becker NQ, Nadeau KC, Saligrama N, Davis MM. Li J, et al. Science. 2022 Apr 15;376(6590):eabi9591. doi: 10.1126/science.abi9591. Epub 2022 Apr 15. Science. 2022. PMID: 35258337 Free PMC article.

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