The role of short-chain fatty acids in Clostridioides difficile infection: A review
- PMID: 35545183
- DOI: 10.1016/j.anaerobe.2022.102585
The role of short-chain fatty acids in Clostridioides difficile infection: A review
Abstract
Clostridioides difficile is a Gram-positive, obligate anaerobic, spore-producing intestinal opportunistic pathogen. CDI outbreaks in Europe and the Americas in recent years are a major health concern. Intestinal short-chain fatty acids (SCFAs) are an important energy source for colonic epithelial cells, and the roles of SCFAs in reducing intestinal inflammation, inhibiting intestinal tumors, and regulating gut microbial homeostasis are being actively researched. Furthermore, SCFAs attenuate CDI or directly inhibit C. difficile growth through different pathways in vivo and in vitro. This review assesses the role of SCFAs in CDI and discusses the potential use of these molecules as therapeutic targets for CDI.
Keywords: Clostridioides difficile; Fecal microbiota transplantation; Immunity; Inflammation; Intestinal microbiota; Short-chain fatty acids.
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
Conflict of interest statement
Declaration of competing interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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