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. 2022 May 11;12(5):e048242.
doi: 10.1136/bmjopen-2020-048242.

Cohort profile: The Xinjiang Multiethnic Cohort (XMC) study

Luo Tao #  1 , Tian Tian #  2 , Lirong Liu  1 , Zewen Zhang  1 , Qi Sun  3 , Gaofeng Sun  4 , Jianghong Dai  5 , Hong Yan  6
Affiliations

Cohort profile: The Xinjiang Multiethnic Cohort (XMC) study

Luo Tao et al. BMJ Open. .

Abstract

Purpose: To investigate the potential causal link between heredity, geographical environment, diet and other lifestyle factors with long-term health consequences, we established the Xinjiang Multiethnic Cohort Study (XMC), the first large-scale prospective cohort in Xinjiang, China.

Participants: XMC commenced in 2018 and enrolled participants from three study sites (Urumqi, Hotan and Ili) in Xinjiang, China. Data collected include standard baseline questionnaire, physical measurement, biological specimen. In addition, about one-third of participants were assessed habitual diet by a more detailed semiquantitative food frequency questionnaire which included 127 foods items at baseline FINDINGS TO DATE: Finally, a total of 30 949 participants, with 32.37% from Urumqi, 41.75% from Hotan, and 25.88% from Ili were recruited in XMC. The average age of participants was 56.21 years for men, and 54.75 years for women. More than 60% of participants in all three survey sites reported an average consumption of fruit and vegetable three or more times per week. In Hotan and Ili, the staple food was wheaten food, whereas, in Urumqi, rice and wheaten food was the food staples. Consumption of white meat, such as fish and poultry, was lower in the three survey locations. Based on self-reported disease from study participants, the five most common chronic diseases among participants across all three survey locations were dyslipidaemia, hypertension, cholecystitis, diabetes, ischaemic heart disease.

Future plans: First, we will collect all health-related records of the study participants in January each year for the previous year. Second, 10% of subjects were randomly selected for telephone follow-up in the final year of cohort building. Finally, as planned, we will revisit the study subjects on site every 2-3 years. Again, we will conduct face-to-face questionnaires and collect biological specimens such as blood and urine from the study subjects.

Keywords: diabetes & endocrinology; epidemiology; public health.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Locations of ongoing prospective cohorts in China. CKB, China Kadoorie Biobank; SMLC, Shandong multicentre Longitudinal Cohort; TCLSIH, Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study; TZL, Taizhou Longitudinal Study; XMC, Xinjiang Multiethnic Cohort.
Figure 2
Figure 2
Map of Xinjiang, China, showing the locations of three surveyed sites (red five-pointed StAR) in the XMC. XMC, Xinjiang Multiethnic Cohort.
Figure 3
Figure 3
Percentage of common food intake in different sites in the XMC. XMC, Xinjiang Multiethnic Cohort.
See this image and copyright information in PMC

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