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. 2022 May 11;22(1):400.
doi: 10.1186/s12884-022-04725-9.

Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women

Caihong Luo #  1 , Zhiju Li #  2 , Yunya Lu  3 , Fang Wei  3 , Dongmei Suo  3 , Shiyan Lan  3 , Zhengyuan Ren  4 , Runchang Jiang  5 , Fang Huang  3 , Aiyue Chen  3 , Liejun Jiang  6 , Huayi Huang  7   8   9 , Xiaoling Guo  10
Affiliations

Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women

Caihong Luo et al. BMC Pregnancy Childbirth. .

Abstract

Background: The association between serum 25-hydroxy vitamin D (25(OH)D) status and gestational diabetes mellitus (GDM) gained attention in recent years, however the conclusion is still controversial due to many interfering factors, such as region of living, environment, lifestyle, and food supplements. Other metabolites (laboratory parameters) are also important in reflecting gestational states. This study aimed to investigate the association of serum 25(OH)D status in early pregnancy with GDM and other laboratory parameters in pregnant women.

Methods: A total of 1516 pregnant women whose blood glucose were normal before pregnancy in the city of Foshan in Guangdong, China were enrolled in this study. GDM was diagnosed between 24 to 28 weeks of pregnancy following the guidelines from the American Diabetes Association. Maternal serum 25(OH)D and other laboratory parameters-including hematology, coagulation, chemistry, and bone density-were measured utilizing various analytical methods in clinical laboratory at gestational weeks 11 to 14.

Results: The average 25(OH)D concentration was 59.1 ± 12.6 nmol/L. None of the study subjects had 25(OH)D < 25 nmol/L; 434 (28.6%) women had 25(OH)D deficiency (< 50 nmol/L), 882 women (58.2%) had 25(OH)D insufficiency (50-74 mmol/L) and 200 women (13.2%) had 25(OH)D sufficiency (≥ 75 nmol/L). There were 264 (17.4%) women diagnosed with GDM. There was not, however, an association between serum 25(OH)D in early pregnancy and GDM. Interestingly, women with more parity and high serum alkaline phosphatase levels had higher serum 25(OH)D levels. There was a possible positive association between serum 25(OH)D and pre-albumin, and a possible negative association between serum 25(OH)D, creatinine, and thrombin time. This study did not find an association between serum 25(OH)D and bone density.

Conclusions: There were no associations between maternal serum 25(OH)D concentration in early pregnancy and the risk of GDM or bone density. There were, however, correlations between serum 25(OH)D and parity, seasoning at sampling, serum alkaline phosphatase, creatinine, pre-albumin, and coagulation factor thrombin time, which need further study to explain their pathophysiology and clinical significance.

Keywords: 25-hydroxy vitamin D (25(OH)D); Alkaline phosphatase; Gestational diabetes mellitus (GDM); Pre-albumin; Thrombin time.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. DeLuca HF. Overview of general physiologic features and functions of VD. Am J Clin Nutr. 2004;80(6 Suppl):1689S–S1696. doi: 10.1093/ajcn/80.6.1689S. - DOI - PubMed
    1. Schmid A, Walther B. Natural VD content in animal products. Adv Nutr. 2013;4(4):453–462. doi: 10.3945/an.113.003780. - DOI - PMC - PubMed
    1. Karras SN, Wagner CL, Castracane VD. Understanding VD metabolism in pregnancy: From physiology to pathophysiology and clinical outcomes. Metabolism. 2018;86:112–123. doi: 10.1016/j.metabol.2017.10.001. - DOI - PubMed
    1. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–1930. doi: 10.1210/jc.2011-0385. - DOI - PubMed
    1. Bouillon R, Carmeliet G. Vitamin D insufficiency: Definition, diagnosis and management. Best Pract Res Clin Endocrinol Metab. 2018;32:669–684. doi: 10.1016/j.beem.2018.09.014. - DOI - PubMed