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. 2022 May 11;17(1):113.
doi: 10.1186/s13019-022-01876-w.

Quality of life and frailty outcomes following surgical and transcatheter aortic valve replacement

Timothy Luke Surman  1 , John Matthew Abrahams  2 , Jaewon Kim  3 , Hayley Elizabeth Surman  4 , Ross Roberts-Thomson  5 , Joseph Matthew Montarello  5 , James Edwards  2 , Michael Worthington  2 , John Beltrame  4
Affiliations

Quality of life and frailty outcomes following surgical and transcatheter aortic valve replacement

Timothy Luke Surman et al. J Cardiothorac Surg. .

Abstract

Background: Our objective was to report on the prospective outcomes in the areas of depression, quality of life, angina, and frailty in SAVR and TAVR patients with aortic stenosis undergoing aortic valve intervention.

Methods: We recruited 300 patients across 3 groups (TAVR, SAVR, and CABG) over 12 months. Depression, quality of life, frailty, and angina were assessed followed by propensity score matching.

Results: Using logistical regression when all patient factors considered for all patients who had SAVR and TAVR, the only preoperative factors that impacted on 1 year mortality was hypertension and STS score. Quality of life improvements within each group over 12 months was significant (p value = 0.0001). Depression at 12 months between groups (p value = 0.0395) and within each group was significant (p value = 0.0073 for SAVR and 0.0001 for TAVR). Angina was most frequent in TAVR at 12 months in the QL (p = 0.0001), PL (p = 0.0007), and improvement was significant in the QL (SAVR p = 0.0010, TAVR p = 0.0001) and PL (SAVR p = 0.0002), TAVR p = 0.0007) domains in both groups. Frailty at 12 months improved in both groups, but was greatest in TAVR (p value = 0.00126).

Conclusions: This 12 months follow up of cardiac surgical patients has revealed significant improvement in PROMs and frailty in all groups by 3 months postoperative regardless of surgical or transcatheter approach. Outcome measures of quality of life and frailty could be utilized as a measure of outcome more regularly in patients undergoing aortic valve surgery regardless of approach.

Keywords: Angina; Depression; Frailty; PROMS; Quality of life.

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Conflict of interest statement

Nil competing interests from listed authors.

Figures

Fig. 1
Fig. 1
Bar graph showing the distribution of QOL results within each domain amongst all groups
Fig. 2
Fig. 2
Bar graph showing the distribution of QOL scores according to patients own health score as measured by VAS
Fig. 3
Fig. 3
Bar graph showing the distribution of depression scores over 12 months across all groups
Fig. 4
Fig. 4
Bar graph showing the distribution of frailty scores over 12 months across all groups
Fig. 5
Fig. 5
Bar graph showing the domain scores in the SAQ7 questionnaire including the patient SAQ health score over the 12 months study period
See this image and copyright information in PMC

References

    1. Food and Drug Administration (2009) Guidance for industry: Patient-reported outcome measures: use in medical product development to support labelling claims. U.S. Department of Health and Human Services, Food and Drug Administration.
    1. Dawson J, Doll H, Fitzpatrick R, Jenkinson C, Carr A. The routine use of patient reported outcome measures in healthcare settings. BMJ. 2010;340:186. doi: 10.1136/bmj.c186. - DOI - PubMed
    1. Deshpande P, Rajan S, Sudeepthi B, Abdul-Nazir C. Patient-reported outcomes: a new era in clinical research. Perspect Clin Res. 2011;2(4):137–144. doi: 10.4103/2229-3485.86879. - DOI - PMC - PubMed
    1. Tseng E, Lee C, Cameron D, Stuart R, Greene P, Sussman M, Watkins L, Gardner T, Baumgartner W. Aortic valve replacement in the elderly. Risk factors and long-term results. Ann Surg. 1997;225:793–802. doi: 10.1097/00000658-199706000-00017. - DOI - PMC - PubMed
    1. Stenman M, Sartipy U. Depression screening in cardiac surgery patients. Heart Lung Circ. 2019;28:953–958. doi: 10.1016/j.hlc.2018.04.298. - DOI - PubMed

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