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. 2023 Feb 1;108(2):645-652.
doi: 10.3324/haematol.2021.280055.

Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation

Annalisa Ruggeri  1 , Liesbeth C De Wreede  2 , Carlheinz R Müller  3 , Pietro Crivello  4 , Edouard F Bonneville  2 , Effie W Petersdorf  5 , Gerard Socié  6 , Valérie Dubois  7 , Riitta Niittyvuopio  8 , Juha Peräsaari  9 , Ibrahim Yakoub-Agha  10 , Jan J Cornelissen  11 , Lotte Wieten  12 , Tobias Gedde-Dahl  13 , Edouard Forcade  14 , Charles R Crawley  15 , Steven G E Marsh  16 , Virginie Gandemer  17 , Eleni Tholouli  18 , Claude-Eric Bulabois  19 , Anne Huynh  20 , Goda Choi  21 , Eric Deconinck  22 , Maija Itäla-Remes  23 , Stig Lenhoff  24 , Mats Bengtsson  25 , Jan-Erik Johansson  26 , Gwendolyn Van Gorkom  27 , Jorinde D Hoogenboom  28 , Luca Vago  1 , Vanderson Rocha  29 , Chiara Bonini  1 , Christian Chabannon  30 , Katharina Fleischhauer  31
Affiliations

Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation

Annalisa Ruggeri et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Univariable associations between combined HLA-DPB1 T-cell epitope and expression matching and outcome afer 8/8 HLA-matched unrelated donor hematopoietic cell transplantation. Five-year outcome probabilities (A,B) or (C) 5-year cumulative incidence are shown for HLA-DPB1 T-cell epitope (TCE)-permissive and high expression (TPHE) mismatches, other (i.e. non-TPHE) mismatches or allele matches. (A) Relapse-free survival (RFS) (49% [95% CI: 44-53%], 42% [95% CI: 40-45%] or 39% [95% CI: 36-43%], P=0.007), (B) non-relapse mortality (NRM) (23% [95% CI: 19-27%], 24% [95% CI: 22-26%], 20% [95% CI: 18-23%], P=0.01), (C) relapse (28% [95% CI: 24-32%], 32% [95% CI: 30-34%], 39% [95% CI: 36-42%], P<0.001). Overall survival and relapse-free survival were assessed using the Kaplan-Meier (KM) method, with reverse KM for determination of median follow-up. Univariable comparisons were performed using the log-rank test. Outcomes with competing risks were assessed using cumulative incidence curves and univariable comparisons for these outcomes were performed using the Gray test. For each of relapse, acute GvHD, and chronic GvHD, death without the event of interest was a competing event, as was second transplantation.
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References

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