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. 2022 Feb-Mar:12031:120313R.
doi: 10.1117/12.2613212. Epub 2022 Apr 4.

Scanner-specific validation of a CT simulator using a COPD-emulated anthropomorphic phantom

Sachin S Shankar  1   2 , Giavanna L Jadick  1 , Eric A Hoffman  3   4 , Jarron Atha  3 , Jessica C Sieren  3   4 , Ehsan Samei  1   2 , Ehsan Abadi  1   2
Affiliations

Scanner-specific validation of a CT simulator using a COPD-emulated anthropomorphic phantom

Sachin S Shankar et al. Proc SPIE Int Soc Opt Eng. 2022 Feb-Mar.

Abstract

Traditional methods of quantitative analysis of CT images typically involve working with patient data, which is often expensive and limited in terms of ground truth. To counter these restrictions, quantitative assessments can instead be made through Virtual Imaging Trials (VITs) which simulate the CT imaging process. This study sought to validate DukeSim (a scanner-specific CT simulator) utilizing clinically relevant biomarkers for a customized anthropomorphic chest phantom. The physical phantom was imaged utilizing two commercial CT scanners (Siemens Somatom Force and Definition Flash) with varying imaging parameters. A computational version of the phantom was simulated utilizing DukeSim for each corresponding real acquisition. Biomarkers were computed and compared between the real and virtually acquired CT images to assess the validity of DukeSim. The simulated images closely matched the real images both qualitatively and quantitatively, with the average biomarker percent difference of 3.84% (range 0.19% to 18.27%). Results showed that DukeSim is reasonably well validated across various patient imaging conditions and scanners, which indicates the utility of DukeSim for further VIT studies where real patient data may not be feasible.

Keywords: Anthropomorphic Phantom; CT; CT Quantification; DukeSim; Image Quality Validation; Kyoto-Kagaku; Virtual Imaging Trial.

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Figures

Figure 1.
Figure 1.
Diagram of the modified Kyoto Kagaku chest phantom and each of the three tube configurations
Figure 1.
Figure 1.
Diagram of the modified Kyoto Kagaku chest phantom and each of the three tube configurations
Figure 2.
Figure 2.
Cross-sectional views of the computational version of the Kyoto Kagaku Chest Phantom, seen from an axial (left), sagittal (middle), and coronal (right) plane.
Figure 3.
Figure 3.
Axial cross-sectional views of the real (left column) versus simulated (right column) images for both the Siemens Flash (top row) and Force (bottom row) scanners. Level: −437.5, Width: 1173.
Figure 4.
Figure 4.
Visual comparisons of each biomarker for each scanner, split by biomarker unit: HU (top), % (bottom left), and cm3/g (bottom right). Note that RT = Right tube, LPT = Left Posterior Tube, LAT = Left Anterior Tube.
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References

    1. Bosch de Basea M et al., “Trends and patterns in the use of computed tomography in children and young adults in Catalonia — results from the EPI-CT study,” Pediatric Radiology, vol. 46, no. 1, pp. 119–129, 2016/January/01 2016, doi: 10.1007/s00247-015-3434-5. - DOI - PMC - PubMed
    1. Fred HL, “Drawbacks and limitations of computed tomography: views from a medical educator,” (in eng), Tex Heart Inst J, vol. 31, no. 4, pp. 345–348, 2004. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/15745283. - PMC - PubMed
    1. Abadi E et al., “Virtual clinical trials in medical imaging: a review,” (in eng), J Med Imaging (Bellingham), vol. 7, no. 4, p. 042805, Jul 2020, doi: 10.1117/1.Jmi.7.4.042805. - DOI - PMC - PubMed
    1. Abadi E et al., “Development of a scanner-specific simulation framework for photon-counting computed tomography,” Biomedical physics & engineering express, vol. 5, no. 5, p. 055008, 2019. - PMC - PubMed
    1. Jadick G, Abadi E, Harrawood B, Sharma S, Segars WP, and Samei E, “A scanner-specific framework for simulating CT images with tube current modulation,” (in eng), Phys Med Biol, vol. 66, no. 18, Sep 13 2021, doi: 10.1088/1361-6560/ac2269. - DOI - PMC - PubMed

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