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. 2022 May 5:14:1671-1682.
doi: 10.2147/CMAR.S358310. eCollection 2022.

Fibrinogen-Albumin Ratio Index Exhibits Predictive Value of Neoadjuvant Chemotherapy in Osteosarcoma

Zhendong Li #  1 , Chenliang Zhou #  2 , Qing Peng #  3 , Suguo Wang  3 , Guowei Qian  2 , Lina Tang  2 , Xin Zhou  4 , Qingcheng Yang  1 , Zan Shen  2 , GaoZhong Huang  3 , Yonggang Wang  2 , Hongtao Li  2
Affiliations

Fibrinogen-Albumin Ratio Index Exhibits Predictive Value of Neoadjuvant Chemotherapy in Osteosarcoma

Zhendong Li et al. Cancer Manag Res. .

Abstract

Purpose: Inflammatory response and nutritional status are associated with cancer development and progression. The present study aimed to evaluate the predictive ability of the fibrinogen-albumin ratio index (FARI) to the efficacy of neoadjuvant chemotherapy (NAC) for osteosarcoma.

Patients and methods: A retrospective analysis involving 752 consecutive osteosarcoma patients between 2012 and 2020 was performed. Data on serum fibrinogen, albumin levels, white blood cell count, platelet count, and alkaline phosphatase (ALP) before and after NAC were collected. The predictive value of the NAC efficacy in osteosarcoma was assessed by constructing a receiver operating characteristic (ROC) curve and calculating the area under the curve (AUC). Prognosis and its predictive factors were analyzed by Kaplan-Meier method and COX regression analysis. Nomogram was established according to selected variables. The predictive performance of the nomogram model was assessed using C-statistics.

Results: A total of 203 patients were included. ROC analysis showed that both FARI before NAC (preFARI; AUC = 0.594, p = 0.032) and the change in FARI before and after NAC (dfFARI = preFARI-postFARI; AUC = 0.652, p = 0.001) exhibited more favorable predictive ability than ALP and other inflammation markers. The preFARI was divided into the high group (>6.1%) and the low group (≤6.1%) based on the optimal cut-off value of 6.1%. Patients with a high preFARI showed significantly decreased metastasis-free survival (MFS) and disease-free survival (DFS) (all p<0.01). In multivariable analysis, preFARI was an independent prognostic marker for patients with osteosarcoma. Predictive nomograms exhibited good ability to predict MFS (C-index = 0.748, se = 0.028) and DFS (C-index=0.727, se = 0.030).

Conclusion: Our findings indicated that FARI exhibits the favorable predictive ability for the efficacy of NAC for osteosarcoma, which could support clinicians and patients in clinical decision-making and treatment optimization.

Keywords: albumin; fibrinogen; fibrinogen–albumin ratio index; neoadjuvant chemotherapy; osteosarcoma; prognosis.

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Conflict of interest statement

The authors declare that they have no competing interests in this work.

Figures

Figure 1
Figure 1
The distribution of FARI (A), NLR (B), LMR (C), PLR (D), SII (E), and ALP (F) before NAC, FARI (I) and ALP (J) after NAC in the good and poor response groups. The change of distribution of FARI (G) and ALP (H) between before NAC and after NAC.
Figure 2
Figure 2
ROC curves for serum markers to discriminate patients’ response to NAC.
Figure 3
Figure 3
Survival analysis of osteosarcoma patients according to different variables. Kaplan-Meier survival curves of MFS (A) and DFS (B) in the two response groups, MFS (C) and DFS (D) in the high and low FARI groups, MFS (E) and DFS (F) in the high and low ALP groups.
Figure 4
Figure 4
Univariate and multivariate analyses for metastasis-free survival (A) and disease-free survival (B).
Figure 5
Figure 5
Nomogram to predict the probabilities of metastasis-free survival (A) and disease-free survival (B) of osteosarcoma. The example of nomogram in a female patient (C).
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