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Review
. 2022 Apr 25:14:859067.
doi: 10.3389/fnagi.2022.859067. eCollection 2022.

Intracerebral Hemorrhage: The Effects of Aging on Brain Injury

Noah Watson  1 , Frederick Bonsack  1 , Sangeetha Sukumari-Ramesh  1
Affiliations
Review

Intracerebral Hemorrhage: The Effects of Aging on Brain Injury

Noah Watson et al. Front Aging Neurosci. .

Abstract

Intracerebral hemorrhage (ICH) is a devastating subtype of stroke with high rates of mortality and morbidity. ICH patients often suffer devastating and debilitating neurological impairments, from which the majority of victims are unable to fully recover to functional independence. Unfortunately, there is no established medical therapy for ICH, which is partly attributed to the lack of understanding of the complex pathology of the disorder. Despite advanced age being a major risk factor of ICH, most preclinical studies on ICH employed young animal subjects. Due to this discrepancy, the molecular level changes in the aging brain after ICH are largely unknown, limiting the translation of preclinical studies into potential human treatments. The purpose of this review is to highlight the effects of advanced age on ICH- induced brain injury and recovery and to draw attention to current knowledge gaps, which warrant further investigation.

Keywords: aging; intracerebral hemorrhage; iron; microglia; neuroinflammation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic representation of possible mechanisms by which aging could modulate brain damage after ICH resulting in worse neurological outcomes.
See this image and copyright information in PMC

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