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Review
. 2022 Apr 25:14:873697.
doi: 10.3389/fnagi.2022.873697. eCollection 2022.

Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders

Dianjun Zhang  1   2   3 , Xinyu Li  1   2   3 , Baoman Li  1   2   3
Affiliations
Review

Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders

Dianjun Zhang et al. Front Aging Neurosci. .

Abstract

The glymphatic system, a recently discovered macroscopic waste removal system in the brain, has many unknown aspects, especially its driving forces and relationship with sleep, and thus further explorations of the relationship between the glymphatic system and a variety of possible related diseases are urgently needed. Here, we focus on the progress in current research on the role of the glymphatic system in several common central nervous system diseases and mood disorders, discuss the structural and functional abnormalities of the glymphatic system which may occur before or during the pathophysiological progress and the possible underlying mechanisms. We emphasize the relationship between sleep and the glymphatic system under pathological conditions and summarize the common imaging techniques for the glymphatic system currently available. The perfection of the glymphatic system hypothesis and the exploration of the effects of aging and endocrine factors on the central and peripheral regulatory pathways through the glymphatic system still require exploration in the future.

Keywords: astrocyte; central nervous system disease; glymphatic system; mood disorder; sleep.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

    1. Abbott N. J., Patabendige A. A., Dolman D. E., Yusof S. R., Begley D. J. (2010). Structure and function of the blood-brain barrier. Neurobiol. Dis. 37 13–25. 10.1016/j.nbd.2009.07.030 - DOI - PubMed
    1. Ahmed R. M., Newcombe R. E., Piper A. J., Lewis S. J., Yee B. J., Kiernan M. C., et al. (2016). Sleep disorders and respiratory function in amyotrophic lateral sclerosis. Sleep Med. Rev. 26 33–42. 10.1016/j.smrv.2015.05.007 - DOI - PubMed
    1. Albrecht U. (2013). Circadian clocks and mood-related behaviors. Handb. Exp. Pharmacol. 217 227–239. 10.1007/978-3-642-25950-0_9 - DOI - PubMed
    1. Altshuler L. L., Abulseoud O. A., Foland-Ross L., Bartzokis G., Chang S., Mintz J., et al. (2010). Amygdala astrocyte reduction in subjects with major depressive disorder but not bipolar disorder. Bipolar Disord. 12 541–549. 10.1111/j.1399-5618.2010.00838.x - DOI - PubMed
    1. Antonaci F., Nappi G., Galli F., Manzoni G. C., Calabresi P., Costa A. (2011). Migraine and psychiatric comorbidity: a review of clinical findings. J. Headache Pain 12 115–125. 10.1007/s10194-010-0282-4 - DOI - PMC - PubMed

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