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Review
. 2022 May 2:2022:2076680.
doi: 10.1155/2022/2076680. eCollection 2022.

Silk Fibroin Hydrogels Could Be Therapeutic Biomaterials for Neurological Diseases

Chun Yang  1 , Sunao Li  1 , Xinqi Huang  1 , Xueshi Chen  1 , Haiyan Shan  2 , Xiping Chen  1 , Luyang Tao  1 , Mingyang Zhang  1
Affiliations
Review

Silk Fibroin Hydrogels Could Be Therapeutic Biomaterials for Neurological Diseases

Chun Yang et al. Oxid Med Cell Longev. .

Abstract

Silk fibroin, a natural macromolecular protein without physiological activity, has been widely used in different fields, such as the regeneration of bones, cartilage, nerves, and other tissues. Due to irrevocable neuronal injury, the treatment and prognosis of neurological diseases need to be investigated. Despite attempts to propel neuroprotective therapeutic approaches, numerous attempts to translate effective therapies for brain disease have been largely unsuccessful. As a good candidate for biomedical applications, hydrogels based on silk fibroin effectively amplify their advantages. The ability of nerve tissue regeneration, inflammation regulation, the slow release of drugs, antioxidative stress, regulation of cell death, and hemostasis could lead to a new approach to treating neurological disorders. In this review, we introduced the preparation of SF hydrogels and then delineated the probable mechanism of silk fibroin in the treatment of neurological diseases. Finally, we showed the application of silk fibroin in neurological diseases.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The preparation of SF hydrogels.
Figure 2
Figure 2
SF hydrogels play a 3D microenvironment akin to natural ECM.
See this image and copyright information in PMC

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