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. 2019 Mar 11;9(14):8016-8024.
doi: 10.1039/c8ra10485a. eCollection 2019 Mar 6.

Indirect study of the effect of α-tocopherol and acetylsalicylic acid on the mineral composition of bone tissue in the offspring of female rats treated with 2,3,7,8-tetrachlorodibenzo- p-dioxin: long-term observations

Maciej Dobrzynski  1 , Piotr Kuropka  2 , Malgorzata Tarnowska  3 , Krzysztof Dudek  4 , Marzena Styczynska  5 , Anna Leskow  3 , Sara Targonska  6 , Rafal J Wiglusz  6   7
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Indirect study of the effect of α-tocopherol and acetylsalicylic acid on the mineral composition of bone tissue in the offspring of female rats treated with 2,3,7,8-tetrachlorodibenzo- p-dioxin: long-term observations

Maciej Dobrzynski et al. RSC Adv. .

Abstract

This paper discusses problems related to the influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the mineral composition of the calvaria in the offspring of female rats. The female rats were administered with a single dose of TCDD and subsequently, after three-weeks, with α-tocopherol or acetylsalicylic acid. The research focused on analysis of the main mineral elements (Ca, Mg, Fe, Zn). The aim of the study was to determine the effect of dioxins and various doses of drugs on bone mineral composition in a six-month observation period. The mineral composition was analyzed using an atomic spectrometry method. Data were statistically analyzed and verified at a significance level of p = 0.05. The use of α-tocopherol normalizes bone resorption and formation disturbed by TCDD, maintaining the content of the studied elements at the physiological level. In turn, administration of acetylsalicylic acid limits the bone resorption process, which affects the element content.

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Conflict of interest statement

There are no conflicts to declare.

Figures

Fig. 1
Fig. 1. Diagrams illustrating the influence of the analyzed interaction time × TCDD on the content of chemical elements in individual research groups, from the top, reading left to right: calcium, magnesium, iron, zinc.
Fig. 2
Fig. 2. Relative change in the content of the analyzed elements ΔC24 (%) in the calvaria after 24 weeks for the experimental groups.
Fig. 3
Fig. 3. An example diagram of the correlation between the content of calcium and iron in the bones of animals in group 3 between the 1st and 24th week of the experiment.
See this image and copyright information in PMC

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