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. 2022 Apr 25:13:819472.
doi: 10.3389/fphar.2022.819472. eCollection 2022.

Assessing the Association of Element Imbalances With Arsenism and the Potential Application Value of Rosa roxburghii Tratt Juice

Yuyan Xu  1 , Baofei Sun  1 , Qibing Zeng  1 , Shaofeng Wei  1 , Guanghong Yang  1 , Aihua Zhang  1
Affiliations

Assessing the Association of Element Imbalances With Arsenism and the Potential Application Value of Rosa roxburghii Tratt Juice

Yuyan Xu et al. Front Pharmacol. .

Abstract

Endemic arsenism caused by coal burning is a unique type of biogeochemical disease that only exists in China, and it is also a disease of element imbalances. Previous studies have shown that element imbalances are involved in the pathogenesis of arsenic; however, the interaction between the various elements and effective preventive measures have not been fully studied. This study first conducted a cross-sectional study of a total of 365 participants. The results showed that arsenic exposure can increase the content of elements (Al, As, Fe, Hg, K, and Na) in the hair (p < 0.05), but the content of other elements (Ca, Co, Cu, Mn, Mo, P, Se, Sr, V, and Zn) was significantly decreased (p < 0.05). Also, the high level of As, Fe, and Pb and the low level of Se can increase the risk of arsenism (p < 0.05). Further study found that the combined exposure of Fe-As and Pb-As can increase the risk of arsenism, but the combined exposure of Se-As can reduce the risk of arsenism (p < 0.05). In particular, a randomized, controlled, double-blind intervention study reveals that Rosa roxburghii Tratt juice (RRT) can reverse the abovementioned element imbalances (the high level of Al, As, and Fe and the low level of Cu, Mn, Se, Sr, and Zn) caused by arsenic (p < 0.05). Our study provides some limited evidence that the element imbalances (the high level of As, Fe, and Pb and the low level of Se) are the risk factors for the occurrences of arsenism. The second major finding was that RRT can regulate the element imbalances, which is expected to improve arsenism. This study provides a scientific basis for further understanding a possible traditional Chinese health food, RRT, as a more effective detoxication of arsenism.

Keywords: Rosa roxburghii Tratt; arsenism; cross-sectional study; element imbalance; intervention study.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The content of 23 elements in the hair of different groups. In this study, the median and interquartile range were expressed in the results, *p < 0.05. Based on exposure grouping, (A–D) the content of potentially toxic elements, constant elements, probably essential trace elements, and essential trace elements in different groups, respectively, is shown. Subsequently, based on disease grouping, the differences of potentially toxic elements, constant elements, probably essential trace elements, and essential trace elements in the two groups are clearly shown (E–H).
FIGURE 2
FIGURE 2
Association and risk between the element’s disorder and arsenism *p < 0.05. The univariate logistic regression analysis (A–E) shows the association and risk between the potentially toxic elements, constant elements, probably essential trace elements, essential trace elements, other factors, and arsenism, respectively. After adjusting for age, gender, smoking status, and drinking alcohol status, further multivariate logistic regression analysis results between the element’s disorder and arsenism are clearly shown (F).
FIGURE 3
FIGURE 3
The linear and non-linear dose–response relationships between the content of As, Fe, Pb, Se, and arsenism. Restricted cubic splines are used to show the linear and non-linear dose–response relationships between the content of As, Fe, Pb, and Se and arsenism. The red box clearly shows that there is a significant non-linear dose–effect relationship between Fe and arsenism.
FIGURE 4
FIGURE 4
The interaction between the content of As, Fe, Pb, and Se for arsenism, *p < 0.05. (A) The interaction analysis results of As, Fe, Pb, and Se and arsenism. (B) The dose–response relationship between the effects of As, Fe, Pb, and Se alone and their combination on the pathogenicity of arsenism. As the color changes from green to yellow and then to red, the pathogenicity of arsenism gradually increases.
FIGURE 5
FIGURE 5
Potential application value of RRT on the element imbalances in the population with arsenism. In this study, the median and interquartile range were expressed in the results, *p < 0.05. (A) The changes in the content of potentially toxic elements. (B) The changes in the content of constant elements. (C) The changes in the content of probably essential trace elements. (D) The changes in the content of essential trace elements.
FIGURE 6
FIGURE 6
Association of element imbalances with arsenism and the potential application value of RRT.
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References

    1. Agrawal S., Bhatnagar P., Flora S. J. (2015). Changes in Tissue Oxidative Stress, Brain Biogenic Amines and Acetylcholinesterase Following Co-exposure to lead, Arsenic and Mercury in Rats. Food Chem. Toxicol. 86, 208–216. 10.1016/j.fct.2015.10.013 - DOI - PubMed
    1. Agusa T., Kunito T., Fujihara J., Kubota R., Minh T. B., Kim Trang P. T., et al. (2006). Contamination by Arsenic and Other Trace Elements in Tube-Well Water and its Risk Assessment to Humans in Hanoi, Vietnam. Environ. Pollut. 139, 95–106. 10.1016/j.envpol.2005.04.033 - DOI - PubMed
    1. Aktar S., Jahan M., Alam S., Mohanto N. C., Arefin A., Rahman A., et al. (2017). Individual and Combined Effects of Arsenic and Lead on Behavioral and Biochemical Changes in Mice. Biol. Trace Elem. Res. 177, 288–296. 10.1007/s12011-016-0883-0 - DOI - PubMed
    1. Alarcón-Herrera M. T., Bundschuh J., Nath B., Nicolli H. B., Gutierrez M., Reyes-Gomez V. M., et al. (2013). Co-occurrence of Arsenic and Fluoride in Groundwater of Semi-arid Regions in Latin America: Genesis, Mobility and Remediation. J. Hazard. Mater. 262, 960–969. 10.1016/j.jhazmat.2012.08.005 - DOI - PubMed
    1. An H. J., Kim I. T., Park H. J., Kim H. M., Choi J. H., Lee K. T. (2011). Tormentic Acid, a Triterpenoid Saponin, Isolated from Rosa Rugosa, Inhibited LPS-Induced iNOS, COX-2, and TNF-α Expression through Inactivation of the Nuclear Factor-Κb Pathway in RAW 264.7 Macrophages. Int. Immunopharmacol 11, 504–510. 10.1016/j.intimp.2011.01.002 - DOI - PubMed