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. 2018 Oct 3;8(59):33968-33971.
doi: 10.1039/c8ra07212d. eCollection 2018 Sep 28.

Transition metal/Brønsted acid cooperative catalysis enabled facile synthesis of 8-hydroxyquinolines through one-pot reactions of ortho-aminophenol, aldehydes and alkynes

Shuyan Yu  1 , Jingxin Wu  1 , Hongbing Lan  1 , Hanwen Xu  1 , Xiaofei Shi  1 , Xuewen Zhu  1 , Zhigang Yin  1
Affiliations

Transition metal/Brønsted acid cooperative catalysis enabled facile synthesis of 8-hydroxyquinolines through one-pot reactions of ortho-aminophenol, aldehydes and alkynes

Shuyan Yu et al. RSC Adv. .

Abstract

A convenient and straightforward three-component one-pot strategy has been developed for the synthesis of 8-hydroxyquinoline derivatives. Under the cooperative catalysis of silver(i) triflate and trifluoroacetic acid, ortho-aminophenol reacted with a range of aldehydes and alkynes under mild reactions, affording the corresponding 8-hydroxyquinoline derivatives with good to excellent yields. These transformations exhibited exceptional substrate generality and functional group compatibility.

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Conflict of interest statement

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Figures

Scheme 1
Scheme 1. Possible synthetic pathway for 8-hydroxyquinoline.
See this image and copyright information in PMC

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