Therapeutic Targeting of the Respiratory Microbiome

doi:10.1164/rccm.202112-2704PP

. 2022 Sep 1;206(5):535-544.

doi: 10.1164/rccm.202112-2704PP.

Therapeutic Targeting of the Respiratory Microbiome

Sanjay H Chotirmall^{1

2}, Debby Bogaert^{3

4}, James D Chalmers⁵, Michael J Cox⁶, Philip M Hansbro^{7

8}, Yvonne J Huang^{9

10}, Philip L Molyneaux¹¹, David N O'Dwyer⁹, Alexa A Pragman^{12

13}, Geraint B Rogers^{14

15}, Leopoldo N Segal¹⁶, Robert P Dickson^{9

10

17}

Affiliations

¹ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
² Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore.
³ Center for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.
⁴ Department of Paediatric Immunology and Infectious Diseases, University Medical Center Utrecht, Utrecht, the Netherlands.
⁵ Division of Molecular and Clinical Medicine, University of Dundee, Dundee, United Kingdom.
⁶ Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
⁷ Centre for Inflammation, Centenary Institute and University of Technology Sydney, Sydney, New South Wales, Australia.
⁸ Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, New South Wales, Australia.
⁹ Division of Pulmonary and Critical Care Medicine, Department of Medicine, and.
¹⁰ Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan.
¹¹ National Heart and Lung Institute, Imperial College London, London, United Kingdom.
¹² Department of Medicine, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota.
¹³ Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
¹⁴ Microbiome and Host Health, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
¹⁵ Infection and Immunity, Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
¹⁶ Division of Pulmonary, Critical Care, and Sleep Medicine, New York University Grossman School of Medicine, NYU Langone Health, New York, New York; and.
¹⁷ Weil Institute for Critical Care Research and Innovation, Ann Arbor, Michigan.

PMID: 35549655
PMCID: PMC9716896
DOI: 10.1164/rccm.202112-2704PP

Therapeutic Targeting of the Respiratory Microbiome

Sanjay H Chotirmall et al. Am J Respir Crit Care Med. 2022.

. 2022 Sep 1;206(5):535-544.

doi: 10.1164/rccm.202112-2704PP.

Authors

Affiliations

¹ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
² Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore.
³ Center for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.
⁴ Department of Paediatric Immunology and Infectious Diseases, University Medical Center Utrecht, Utrecht, the Netherlands.
⁵ Division of Molecular and Clinical Medicine, University of Dundee, Dundee, United Kingdom.
⁶ Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
⁷ Centre for Inflammation, Centenary Institute and University of Technology Sydney, Sydney, New South Wales, Australia.
⁸ Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, New South Wales, Australia.
⁹ Division of Pulmonary and Critical Care Medicine, Department of Medicine, and.
¹⁰ Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan.
¹¹ National Heart and Lung Institute, Imperial College London, London, United Kingdom.
¹² Department of Medicine, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota.
¹³ Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
¹⁴ Microbiome and Host Health, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
¹⁵ Infection and Immunity, Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
¹⁶ Division of Pulmonary, Critical Care, and Sleep Medicine, New York University Grossman School of Medicine, NYU Langone Health, New York, New York; and.
¹⁷ Weil Institute for Critical Care Research and Innovation, Ann Arbor, Michigan.

PMID: 35549655
PMCID: PMC9716896
DOI: 10.1164/rccm.202112-2704PP

No abstract available

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Figures

**Figure 1.**
Therapeutic targeting of the respiratory microbiome: (A) current practice and challenges and (B) future opportunities. To therapeutically modulate the respiratory microbiome effectively, we must advance our means of sampling, measuring, analyzing, interpreting, and intervening on respiratory microbiota. Progress requires a rapid and accurate assessment of the microbiologic and clinical response of interventions. GC-MS = gas chromatography–mass spectrometry; HME = heat and moisture exchange; ITS = internal transcribed spacer; QIIME = quantitative insights into microbial ecology; qPCR = quantitative PCR.

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References

1. Dickson RP, Erb-Downward JR, Martinez FJ, Huffnagle GB. The microbiome and the respiratory tract. Annu Rev Physiol . 2016;78:481–504. - PMC - PubMed
1. Hilty M, Burke C, Pedro H, Cardenas P, Bush A, Bossley C, et al. Disordered microbial communities in asthmatic airways. PLoS One . 2010;5:e8578. - PMC - PubMed
1. Dickson RP, Erb-Downward JR, Freeman CM, McCloskey L, Falkowski NR, Huffnagle GB, et al. Bacterial topography of the healthy human lower respiratory tract. MBio . 2017;8:e02287-16. - PMC - PubMed
1. Dickson RP, Erb-Downward JR, Freeman CM, McCloskey L, Beck JM, Huffnagle GB, et al. Spatial variation in the healthy human lung microbiome and the adapted island model of lung biogeography. Ann Am Thorac Soc . 2015;12:821–830. - PMC - PubMed
1. Segal LN, Clemente JC, Tsay JC, Koralov SB, Keller BC, Wu BG, et al. Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype. Nat Microbiol . 2016;1:16031. - PMC - PubMed

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[1] Dickson RP, Erb-Downward JR, Martinez FJ, Huffnagle GB. The microbiome and the respiratory tract. Annu Rev Physiol . 2016;78:481–504. - PMC - PubMed

[2] Dickson RP, Erb-Downward JR, Martinez FJ, Huffnagle GB. The microbiome and the respiratory tract. Annu Rev Physiol . 2016;78:481–504. - PMC - PubMed

[3] Hilty M, Burke C, Pedro H, Cardenas P, Bush A, Bossley C, et al. Disordered microbial communities in asthmatic airways. PLoS One . 2010;5:e8578. - PMC - PubMed

[4] Hilty M, Burke C, Pedro H, Cardenas P, Bush A, Bossley C, et al. Disordered microbial communities in asthmatic airways. PLoS One . 2010;5:e8578. - PMC - PubMed

[5] Dickson RP, Erb-Downward JR, Freeman CM, McCloskey L, Falkowski NR, Huffnagle GB, et al. Bacterial topography of the healthy human lower respiratory tract. MBio . 2017;8:e02287-16. - PMC - PubMed

[6] Dickson RP, Erb-Downward JR, Freeman CM, McCloskey L, Falkowski NR, Huffnagle GB, et al. Bacterial topography of the healthy human lower respiratory tract. MBio . 2017;8:e02287-16. - PMC - PubMed

[7] Dickson RP, Erb-Downward JR, Freeman CM, McCloskey L, Beck JM, Huffnagle GB, et al. Spatial variation in the healthy human lung microbiome and the adapted island model of lung biogeography. Ann Am Thorac Soc . 2015;12:821–830. - PMC - PubMed

[8] Dickson RP, Erb-Downward JR, Freeman CM, McCloskey L, Beck JM, Huffnagle GB, et al. Spatial variation in the healthy human lung microbiome and the adapted island model of lung biogeography. Ann Am Thorac Soc . 2015;12:821–830. - PMC - PubMed

[9] Segal LN, Clemente JC, Tsay JC, Koralov SB, Keller BC, Wu BG, et al. Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype. Nat Microbiol . 2016;1:16031. - PMC - PubMed

[10] Segal LN, Clemente JC, Tsay JC, Koralov SB, Keller BC, Wu BG, et al. Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype. Nat Microbiol . 2016;1:16031. - PMC - PubMed

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Therapeutic Targeting of the Respiratory Microbiome

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Therapeutic Targeting of the Respiratory Microbiome

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