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. 2022 Sep 15;206(6):696-703.
doi: 10.1164/rccm.202111-2547PP.

Susceptibility of Patients with Airway Disease to SARS-CoV-2 Infection

Francesca M Conway  1   2   3 , Chloe I Bloom  3 , Pallav L Shah  1   2   3
Affiliations

Susceptibility of Patients with Airway Disease to SARS-CoV-2 Infection

Francesca M Conway et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
A simplified summary of the proposed mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry in airways disease. The spike protein on SARS-CoV-2 binds to ACE-2 as an entry receptor in airway epithelial cells and undergoes priming by TMPRSS2. This allows entry into the host cell. There are other proteins also involved not included in the diagram for simplicity. ACE-2 = angiotensin-converting enzyme-2; COPD = chronic obstructive pulmonary disease; ICS = inhaled corticosteroids; protein-S = spike protein; TMPRSS2 = transmembrane protease serine 2.
See this image and copyright information in PMC

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