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Meta-Analysis
. 2022 May 6;101(18):e29191.
doi: 10.1097/MD.0000000000029191.

The effect of 0.01% atropine and orthokeratology on ocular axial elongation for myopia children: A meta-analysis (a PRISMA-compliant article)

Yan Yu  1 , Jiasu Liu  2
Affiliations
Meta-Analysis

The effect of 0.01% atropine and orthokeratology on ocular axial elongation for myopia children: A meta-analysis (a PRISMA-compliant article)

Yan Yu et al. Medicine (Baltimore). .

Retraction in

Abstract

Objectives: This meta-analysis aimed to identify the therapeutic effect of 0.01% atropine with orthokeratology on ocular axial elongation for myopia children.

Methods: We searched PubMed, Cochrane Library, and CBM databases from inception to July 1st, 2021. Meta-analysis was conducted using STATA version 14.0 and Review Manager version 5.3 softwares. We calculated the weighted mean differences to analyze the change of ocular axial length (AL) between orthokeratology combined with 0.01% atropine (OKA) and) alone. The Cochran's Q-statistic and I2 test were used to evaluate potential heterogeneity between studies. To evaluate the influence of single studies on the overall estimate, a sensitivity analysis was performed. We also performed sub group and meta-regression analyses to investigate potential sources of heterogeneity. We conducted Begger funnel plots and Egger linear regression tests to investigate publication bias.

Results: Nine studies that met all inclusion criteria were included in this meta-analysis. A total of 191 children in OKA group and 196 children in orthokeratology (OK) group were assessed. The pooled summary weighted mean differences of AL change was -0.90 (95% CI = -1.25-0.55) with statistical significance (t = -5.03, P < .01), which indicated there was obvious difference between OKA and OK in myopic children. Subgroup analysis also showed that OKA treatment resulted in significantly less axial elongation compared to OK treatment alone according to SER. We found no evidence for publication bias.

Conclusions: Our meta-analysis indicates 0.01% atropine atropine is effective in slowing axial elongation in myopia children with orthokeratology.

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Conflict of interest statement

The authors have no funding and conflicts of interests to disclose.

Figures

Figure 1
Figure 1
Flow chart of literature search and study selection. Nine studies were included in this meta-analysis.
Figure 2
Figure 2
Risk of bias summary of quality evaluation of included randomized controlled trials.
Figure 3
Figure 3
Risk of bias graph of quality evaluation of included randomized controlled trials.
Figure 4
Figure 4
Overall and subgroup analysis forest plot of the effect of 0.01% atropine on ocular axial elongation for myopia children.
Figure 5
Figure 5
Sensitivity analysis. None of included studies caused obvious interference to the results of this meta-analysis.
Figure 6
Figure 6
Begger funnel plot of publication bias. No publication bias was detected in this meta-analysis.
See this image and copyright information in PMC

References

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