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. 2023;52(1):68-74.
doi: 10.1159/000524644. Epub 2022 May 12.

Efficacy and Safety of the Medium Cut-Off Elisio HX Dialyzer

Francisco Maduell  1   2 , José Jesús Broseta  1 , Diana Rodríguez-Espinosa  1 , Jimena Del Risco-Zevallos  1 , Miquel Gómez  1 , Lida M Rodas  1 , Marta Arias-Guillén  1 , Manel Vera  1 , Néstor Fontseré  1 , Maria Del Carmen Salgado  3 , Nayra Rico  3
Affiliations

Efficacy and Safety of the Medium Cut-Off Elisio HX Dialyzer

Francisco Maduell et al. Blood Purif. 2023.

Abstract

Introduction: The medium cut-off Elisio HX dialyzer by Nipro became commercially available in Europe in 2021, but there are still no reports of in vivo data. This study aimed to evaluate the safety and efficacy of it compared with previously evaluated hemodialysis (HD), expanded HD (HDx), and postdilution hemodiafiltration (HDF) treatments.

Methods: A prospective study was carried out on 18 patients who underwent 5 dialysis sessions: FX80 Cordiax in HD, Elisio H19 in HD, Elisio HX19 in HDx, Theranova 400 in HDx, and FX80 Cordiax in HDF. The reduction ratios of urea, creatinine, ß2-microglobulin, myoglobin, kappa FLC, prolactin, α1-microglobulin, α1-acid glycoprotein, lambda FLC, and albumin were compared. Dialysate albumin loss was measured.

Results: The comparison between the different dialysis modalities revealed no difference for small molecules, but HDx and HDF were significantly more efficient than HD for medium and large molecule removal. The efficacy of Elisio HX19 dialyzer in HDx was similar to the Theranova 400, superior to both dialyzers in HD, and slightly lower than HDF. Albumin losses in dialysate with HD dialyzers were less than 1 g, but between 1.5 and 2.5 g in HDx and HDF. The global removal score (GRS) values with HDx treatments were statistically significantly higher than those with HD. The highest GRS was obtained with the helixone dialyzer in HDF.

Conclusions: The new MCO dialyzer, Elisio HX, performs with excellent behavior and tolerance. It represents an upgrade compared to their predecessor and is very close to the removal capacity of HDF treatment.

Keywords: Dialyzer performance; Expanded hemodialysis; Helixone; Hemodiafiltration; Polyethersulfone.

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Conflict of interest statement

The authors declare no financial support for the project. Francisco Maduell has received consultancy fees and lecture fees from Baxter, Fresenius Medical Care, Medtronic, Nipro, Toray, and Vifor. The other authors have no conflict of interest to declare.

Figures

Fig. 1
Fig. 1
Comparison of albumin loss in all study situations (ANOVA for repeated data).
Fig. 2
Fig. 2
Global evaluation of removal efficacy for medium-sized molecules and albumin loss in all study situations: GRS (ANOVA for repeated data).
See this image and copyright information in PMC

References

    1. Belmouaz M, Bauwens M, Hauet T, Bossard V, Jamet P, Joly F, et al. Comparison of the removal of uraemic toxins with medium cut-off and high-flux dialysers: a randomized clinical trial. Nephrol Dial Transplant. 2020;35:328–335. - PubMed
    1. García-Prieto A, Vega A, Linares T, Abad S, Macías N, Aragoncillo I, et al. Evaluation of the efficacy of a medium cut-off dialyser and comparison with other high-flux dialysers in conventional haemodialysis and online haemodiafiltration. Clin Kidney J. 2018;11:742–746. - PMC - PubMed
    1. Maduell F, Broseta JJ, Rodas L, Montagud-Marrahi E, Rodriguez-Espinosa D, Hermida E, et al. Comparison of solute removal properties between high-efficient dialysis modalities in low blood flow rate. Ther Apher Dial. 2020;24:387–392. - PubMed
    1. Maduell F, Moreso F, Pons M, Ramos R, Mora-Macià J, Carreras J, et al. High-efficiency postdilution online hemodiafiltration reduces all-cause mortality in hemodialysis patients. J Am Soc Nephrol. 2013;24:487–497. - PMC - PubMed
    1. Mostovaya IM, Blankestijn PJ, Bots ML, Covic A, Davenport A, Grooteman MP, et al. Clinical evidence on hemodiafiltration: a systematic review and a meta-analysis. Semin Dial. 2014;27:119–127. - PubMed