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. 2022 Oct;306(4):1085-1100.
doi: 10.1007/s00404-022-06583-4. Epub 2022 May 13.

Development and psychometric properties of the human papillomavirus-quality of life (HPV-QoL) questionnaire to assess the impact of HPV on women health-related-quality-of-life

Pluvio J Coronado  1 , Carmen González-Granados  2 , Mar Ramírez-Mena  3 , Javier Calvo  3 , María Fasero  4 , Mónica Bellón  3 , Javier F García-Santos  3 , Javier Rejas-Gutiérrez  5
Affiliations

Development and psychometric properties of the human papillomavirus-quality of life (HPV-QoL) questionnaire to assess the impact of HPV on women health-related-quality-of-life

Pluvio J Coronado et al. Arch Gynecol Obstet. 2022 Oct.

Abstract

Purpose: The HPV-Quality-of-Life (HPV-QoL) questionnaire was developed to determine the impact of Human-Papillomavirus (HPV) infection and related interventions on women health-related quality-of-life. This study provides the development and preliminary psychometric properties of a novel HPV-QoL questionnaire for adult women with HPV.

Methods: After reviewing literature and cognitive debriefing interviews in women who had experienced HPV-related conditions, instrument items and domains were developed. A draft questionnaire was pilot tested for comprehension and ease of completion. Psychometric evaluation of the final HPV-QoL scale was conducted in a psychometric study including 252 adult women derived to our centre by a positive HPV test in the cervical cancer screening program and/or presenting genital warts.

Results: The present study reveals that the HPV-QoL questionnaire, structured in four domains: general well-being [including psychological well-being and social well-being subdomains], health, contagiousness and sexuality, showed good metric properties of feasibility irrespective of age or educational level, and time to administer was less than 5 min. Internal consistency and temporal stability (reliability) showed values above the acceptable standards. The instrument showed its concurrent validity by means of a significant correlation with mental and sexual existing instruments; GHQ-12 and FSFI questionnaires, respectively, and also known groups validity showing significant differences among the subgroups regarding either sexual dysfunction or mental deterioration.

Conclusion: This study provides an HPV-QoL questionnaire with an innovative patient-reported outcomes specific measurement tool to assess HRQoL in women with HPV infection. The present study suggests this questionnaire has satisfactory psychometric properties, including validity and reliability. Results support the use of the HPV-QoL questionnaire as a HRQoL measurement instrument for daily medical practice and clinical research.

Keywords: Development; HPV-QoL questionnaire; Human papillomavirus (HPV) infection; Women health-related quality-of-life.

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Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Figures

Fig. 1
Fig. 1
Conceptual modelling of the Human Papillomavirus-Quality of Life (HPV-QoL) questionnaire
Fig. 2
Fig. 2
Construct validity of the HPV-QoL questionnaire: convergent and divergent validity total to domain, domain to domain and domain to item
Fig. 3
Fig. 3
Known groups validity of HPV-QoL questionnaire in women according to presence of sexual dysfunction (score in questionnaire FSFI ≤ 26.55 points, graph a) or mental deterioration by GHQ-12 questionnaire (≥ 17 points, graph b). FSFI = Female Sexual Function Index de R. Rosen; GHQ-12 = General Health Questionnaire de Golberg de 12 items
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