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. 2022 May;27(19):2100869.
doi: 10.2807/1560-7917.ES.2022.27.19.2100869.

Assessing the effect of non-pharmaceutical interventions on COVID-19 transmission in Spain, 30 August 2020 to 31 January 2021

David García-García  1   2 , Rafael Herranz-Hernández  3 , Ayelén Rojas-Benedicto  1   2 , Inmaculada León-Gómez  1   2 , Amparo Larrauri  1   2 , Marina Peñuelas  2 , María Guerrero-Vadillo  2 , Rebeca Ramis  1   2 , Diana Gómez-Barroso  1   2
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Assessing the effect of non-pharmaceutical interventions on COVID-19 transmission in Spain, 30 August 2020 to 31 January 2021

David García-García et al. Euro Surveill. 2022 May.

Abstract

BackgroundAfter a national lockdown during the first wave of the COVID-19 pandemic in Spain, regional governments implemented different non-pharmaceutical interventions (NPIs) during the second wave.AimTo analyse which implemented NPIs significantly impacted effective reproduction number (Rt) in seven Spanish provinces during 30 August 2020-31 January 2021.MethodsWe coded each NPI and levels of stringency with a 'severity index' (SI) and computed a global SI (mean of SIs per six included interventions). We performed a Bayesian change point analysis on the Rt curve of each province to identify possible associations with global SI variations. We fitted and compared several generalised additive models using multimodel inference, to quantify the statistical effect on Rt of the global SI (stringency) and the individual SIs (separate effect of NPIs).ResultsThe global SI had a significant lowering effect on the Rt (mean: 0.16 ± 0.05 units for full stringency). Mandatory closing times for non-essential businesses, limited gatherings, and restricted outdoors seating capacities (negative) as well as curfews (positive) were the only NPIs with a significant effect. Regional mobility restrictions and limited indoors seating capacity showed no effect. Our results were consistent with a 1- to 3-week-delayed Rt as a response variable.ConclusionWhile response measures implemented during the second COVID-19 wave contributed substantially to a decreased reproduction number, the effectiveness of measures varied considerably. Our findings should be considered for future interventions, as social and economic consequences could be minimised by considering only measures proven effective.

Keywords: COVID-19; Non-Pharmaceutical Interventions (NPIs); Spain; severity index.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure
Figure
Observed effective reproduction number, results of the trend analysis and global severity index during the second wave of the COVID-19 pandemic, Spain, 1 August 2020–31 January 2021 (n = 7 regions)
See this image and copyright information in PMC

References

    1. Gobierno de España. Real Decreto 463/2020, de 14 de marzo, por el que se declara el estado de alarma para la gestión de la situación de crisis sanitaria ocasionada por el COVID-19. [Royal Decree 463/2020, 14 March, declaring the state of alarm for the management of the sanitary crisis caused by COVID-19]. Boletín oficial del estado; 2020. Spanish. Available from: https://www.boe.es/buscar/pdf/2020/BOE-A-2020-3692-consolidado.pdf
    1. Gobierno de España. Orden SND/399/2020, de 9 de mayo, para la flexibilización de determinadas restricciones de ámbito nacional, establecidas tras la declaración del estado de alarma en aplicación de la fase 1 del Plan para la transición hacia una nueva normalidad. [Order SND/399/2020, 9 May, for the easing of certain nation-wide restrictions established after the declaration of the state of alarm in application of phase 1 of the Plan for the transition to a new normality]. Boletín oficial del estado; 2020. Spanish. Available from: https://www.boe.es/eli/es/o/2020/05/09/snd399/dof/spa/pdf
    1. Gobierno de España. Real Decreto 926/2020, de 25 de octubre, por el que se declara el estado de alarma para contener la propagación de infecciones causadas por el SARSCoV-2. [Royal Decree 926/2020, 25 October, declaring the state of alarm to contain the propagation of infectious diseases caused by SARSCoV-2]. Madrid: Boletín oficial del estado; 2020. Spanish. Available from: https://www.boe.es/boe/dias/2020/10/25/pdfs/BOE-A-2020-12898.pdf
    1. David GG, Rafael HH, Ayelén RB, Inmaculada LG, Amparo L, Marina P, et al. Perimeter confinements of basic health zones and COVID-19 incidence in Madrid, Spain. BMC Public Health. 2022;22(1):216. 10.1186/s12889-022-12626-x - DOI - PMC - PubMed
    1. Hyafil A, Moriña D. Analysis of the impact of lockdown on the reproduction number of the SARS-Cov-2 in Spain. Gac Sanit. 2021;35(5):453-8. 10.1016/j.gaceta.2020.05.003 - DOI - PMC - PubMed

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