Molecular diagnostics in severe pneumonia: a new dawn or false promise?

Andrew Conway Morris^{1

2

3}, Lieuwe D J Bos⁴, Saad Nseir^{5

6}

Affiliations

¹ Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, UK.
² Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK.
³ JVF Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK.
⁴ Intensive Care, Amsterdam UMC-Location AMC, University of Amsterdam, Amsterdam, The Netherlands.
⁵ Médecine Intensive-Réanimation, Hôpital R. Salengro, CHU de Lille, 59000, Lille, France. s-nseir@chru-lille.fr.
⁶ Inserm U1285, Université de Lille, CNRS, UMR 8576-UGSF, 59000, Lille, France. s-nseir@chru-lille.fr.

PMID: 35552790
DOI: 10.1007/s00134-022-06722-0

Molecular diagnostics in severe pneumonia: a new dawn or false promise?

Andrew Conway Morris et al. Intensive Care Med. 2022 Jun.

. 2022 Jun;48(6):740-742.

doi: 10.1007/s00134-022-06722-0. Epub 2022 May 13.

Authors

Andrew Conway Morris^{1

2

3}, Lieuwe D J Bos⁴, Saad Nseir^{5

6}

Affiliations

¹ Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, UK.
² Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK.
³ JVF Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK.
⁴ Intensive Care, Amsterdam UMC-Location AMC, University of Amsterdam, Amsterdam, The Netherlands.
⁵ Médecine Intensive-Réanimation, Hôpital R. Salengro, CHU de Lille, 59000, Lille, France. s-nseir@chru-lille.fr.
⁶ Inserm U1285, Université de Lille, CNRS, UMR 8576-UGSF, 59000, Lille, France. s-nseir@chru-lille.fr.

PMID: 35552790
DOI: 10.1007/s00134-022-06722-0

No abstract available

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How to use biomarkers of infection or sepsis at the bedside: guide to clinicians.
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Effect of probiotics on the incidence of acute kidney injury in patients with severe pneumonia.
Zhang Q, Song X. Zhang Q, et al. Front Med (Lausanne). 2025 May 21;12:1596037. doi: 10.3389/fmed.2025.1596037. eCollection 2025. Front Med (Lausanne). 2025. PMID: 40470035 Free PMC article.
Bronchoscopic Diagnosis of Severe Respiratory Infections.
Röder M, Ng AYKC, Conway Morris A. Röder M, et al. J Clin Med. 2024 Oct 9;13(19):6020. doi: 10.3390/jcm13196020. J Clin Med. 2024. PMID: 39408080 Free PMC article. Review.

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References

1. Vincent J-L, Sakr Y, Singer M et al (2020) Prevalence and outcomes of infection among patients in intensive care units in 2017. JAMA 323:1478–1487. https://doi.org/10.1001/jama.2020.2717 - DOI - PubMed - PMC
1. Meduri GU, Mauldin GL, Wunderink RG et al (1994) Causes of fever and pulmonary densities in patients with clinical manifestations of ventilator-associated pneumonia. Chest 106:221–235. https://doi.org/10.1378/chest.106.1.221 - DOI - PubMed
1. Metlay JP, Waterer GW, Long AC et al (2019) Diagnosis and treatment of adults with community-acquired pneumonia. an official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med 200:e45–e67. https://doi.org/10.1164/rccm.201908-1581ST - DOI - PubMed - PMC
1. Woodhead M, Blasi F, Ewig S et al (2011) Guidelines for the management of adult lower respiratory tract infections–full version. Clin Microbiol Infect 17(Suppl 6):E1-59. https://doi.org/10.1111/j.1469-0691.2011.03672.x - DOI - PubMed - PMC
1. Roquilly A, Torres A, Villadangos JA et al (2019) Pathophysiological role of respiratory dysbiosis in hospital-acquired pneumonia. Lancet Respir Med. https://doi.org/10.1016/S2213-2600(19)30140-7 - DOI - PubMed

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Molecular diagnostics in severe pneumonia: a new dawn or false promise?

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Molecular diagnostics in severe pneumonia: a new dawn or false promise?

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