Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec;63(3):490-498.
doi: 10.1007/s12016-022-08940-2. Epub 2022 May 12.

Infections or Vaccines Associated with Finkelstein-Seidlmayer Vasculitis: Systematic Review

Gabriel Bronz  1 , Céline Betti  1 , Pietro O Rinoldi  1 , Lisa Kottanattu  1   2 , Mario G Bianchetti  2   3 , Danilo Consolascio  3 , Marcel M Bergmann  4   5 , Gregorio P Milani  6   7 , Benedetta Terziroli Beretta Piccoli  8   9 , Sebastiano A G Lava  10   11
Affiliations

Infections or Vaccines Associated with Finkelstein-Seidlmayer Vasculitis: Systematic Review

Gabriel Bronz et al. Clin Rev Allergy Immunol. 2022 Dec.

Abstract

Finkelstein-Seidlmayer vasculitis, also referred to as acute hemorrhagic edema of young children, is a rare small-vessel leukocytoclastic vasculitis. This condition is skin-limited, mainly affects infants up to 2 years of age and spontaneously remits. It has been suggested that an infection or a vaccine precede (by ≤ 14 days) this vasculitis. To better understand the interplay between infections or vaccines and Finkelstein-Seidlmayer vasculitis, we utilized the data contained in the Acute Hemorrhagic Edema BIbliographic Database AHEBID. The database, initiated in 2019, is being regularly updated, encompasses the entire original literature on Finkelstein-Seidlmayer vasculitis published after the original description and is attainable on request. The possible existence of an infectious or a vaccine precursor was addressed in 447 cases. Most cases were preceded by an infection (N = 384; 86%), by a vaccination (N = 20; 4.4%), or both an infection and a vaccination (N = 17; 3.8%). No precursor was reported in the remaining cases (N = 26; 5.8%). Two distinct infections preceded the onset of the vasculitis in 11 of the 381 cases with infection-associated Finkelstein-Seidlmayer vasculitis. The following infectious precursors were reported: upper respiratory tract infection (N = 292); acute gastroenteritis (N = 40); a benign febrile infection (N = 36); lower respiratory tract infection (N = 22); further infections (N = 8). The temporal relationship between the infectious precursor and the onset of the skin eruption was detailed in 336 cases: 54 cases developed before resolution and 282 after resolution of the infection. In conclusion, most cases of Finkelstein-Seidlmayer vasculitis are preceded by an infection. In a minority of cases, this skin vasculitis develops before resolution of the infection. In most cases, however, this vasculitis develops after resolution of the infection. More rarely, this vasculitis is preceded by a vaccination.

Keywords: Acute hemorrhagic edema of young children; Cockade purpura with edema; Finkelstein-Seidlmayer vasculitis; Infection; Precursor; Small-vessel leukocytoclastic vasculitis; Vaccination.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Finkelstein-Seidlmayer vasculitis. Flowchart of the literature search. The preferred reporting items for systematic reviews and meta-analyses were followed
Fig. 2
Fig. 2
Finkelstein-Seidlmayer vasculitis. Precursors. The term AHEBID denotes the Acute Hemorrhagic Edema BIbliographic Database
Fig. 3
Fig. 3
Infectious or vaccine precursors noted in 423 patients with Finkelstein-Seidlmayer vasculitis
See this image and copyright information in PMC

References

    1. Fiore E, Rizzi M, Ragazzi M, Vanoni F, Bernasconi M, Bianchetti MG, Simonetti GD. Acute hemorrhagic edema of young children (cockade purpura and edema): a case series and systematic review. J Am Acad Dermatol. 2008;59(4):684–695. doi: 10.1016/j.jaad.2008.06.005. - DOI - PubMed
    1. Ting TV. Diagnosis and management of cutaneous vasculitis in children. Pediatr Clin North Am. 2014;61(2):321–346. doi: 10.1016/j.pcl.2013.11.007. - DOI - PubMed
    1. Rinoldi PO, Bronz G, Ferrarini A, Mangas C, Bianchetti MG, Chelleri C, Lava SAG, Milani GP. Acute hemorrhagic edema: uncommon features. J Am Acad Dermatol. 2021;85(6):1620–1621. doi: 10.1016/j.jaad.2020.12.033. - DOI - PubMed
    1. Lava SAG, Milani GP, Fossali EF, Simonetti GD, Agostoni C, Bianchetti MG. Cutaneous manifestations of small-vessel leukocytoclastic vasculitides in childhood. Clin Rev Allergy Immunol. 2017;53(3):439–451. doi: 10.1007/s12016-017-8626-3. - DOI - PubMed
    1. Rinoldi PO, Milani GP, Bianchetti MG, Ferrarini A, Ramelli GP, Lava SAG. Acute hemorrhagic edema of young children: open questions and perspectives. Int J Dermatol Skin Care. 2019;1:63–67. doi: 10.36811/ijdsc.2019.110003. - DOI

Publication types