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. 2022 Aug;38(8):966-968.
doi: 10.1007/s12264-022-00877-y. Epub 2022 May 12.

Can You Feel the Love Tonight: A Dipeptidergic Circuit for Pleasant Touch

Jing-Jing Yan  1 , Wen Zhang  2 , Xiao-Hong Xu  3
Affiliations

Can You Feel the Love Tonight: A Dipeptidergic Circuit for Pleasant Touch

Jing-Jing Yan et al. Neurosci Bull. 2022 Aug.
No abstract available

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Figures

Fig. 1
Fig. 1
Activation of a dipeptidergic pathway from l/vlPAG tac1+ neurons to PVH oxytocin neurons. A Both ST and chemogenetic activation of PVH oxytocin neurons by hm3Dq lead to better social interaction and conditioned place preference. ST induces higher firing of l/vlPAG tac1+ neurons and PVH oxytocin neurons, which depends on substance P-TACR1 signaling. B l/vlPAG tac1+ neurons release glutamate and substance P in the PVH to activate oxytocin neurons. However, only the substance P-TACR1 signaling contributes to the reduction of transient K+ current. IA channels: transient, A-type, K+ current channels.
See this image and copyright information in PMC

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