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Review
. 2022 May 11;16(Supplement_2):ii30-ii41.
doi: 10.1093/ecco-jcc/jjac011.

Ustekinumab in Crohn's Disease: New Data for Positioning in Treatment Algorithm

Ferdinando D'Amico  1   2 , Laurent Peyrin-Biroulet  3 , Silvio Danese  2
Affiliations
Review

Ustekinumab in Crohn's Disease: New Data for Positioning in Treatment Algorithm

Ferdinando D'Amico et al. J Crohns Colitis. .

Abstract

The treatment of patients with moderate to severe Crohn's disease [CD] is still challenging. Therapeutic options include steroids, immunosuppressants, anti-TNFα agents, vedolizumab, and ustekinumab. Ustekinumab is a monoclonal antibody blocking the p40 subunit of IL-12 and IL-23. It showed to be effective and safe in randomised clinical trials and real-life studies and is currently approved for the management of CD patients who are naive to biologics and those who have already been treated with such medications. However, to date, a detailed and approved therapeutic algorithm is not available. The aim of this review is to report the most recent and updated data on the efficacy and safety of ustekinumab for the treatment of patients with moderate to severe CD and to define the optimal management of these patients.

Keywords: Crohn’s disease; Inflammatory bowel diseases; algorithm; ustekinumab.

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Figures

Figure 1:
Figure 1:
Proposed algorithm for use of ustekinumab in patients with moderate-severe active Crohn’s disease.
Figure 2:
Figure 2:
Strengths and challenges of ustekinumab use in the treatment of Crohn’s disease.
See this image and copyright information in PMC

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