Review
doi: 10.1007/978-3-642-71617-1_18.
Pharmacokinetic factors and their implication in the induction of mouse liver tumors by halogenated hydrocarbons
- PMID: 3555414
- DOI: 10.1007/978-3-642-71617-1_18
Item in Clipboard
Review
Pharmacokinetic factors and their implication in the induction of mouse liver tumors by halogenated hydrocarbons
Arch Toxicol Suppl.
1987.
Abstract
The presently available data on pharmacokinetics of halogenated solvents which produce hepatic tumors in B6C3F1 mice, but not in rats, are reviewed. Such compounds are trichloroethylene, perchloroethylene, 1,1,2-trichloroethane, 1,1,2,2-tetrachloroethane, and dichloromethane. It seems likely that higher metabolic rates in mice (compared with other species) may lead to a species-selective toxicity of such compounds. Recurrent cytotoxicity which leads to stimulation of cell replication seems to be a contributing factor in the pathogenesis of mouse liver tumors. However, it is likely that more than one factor contributes to the unique tumor response of the B6C3F1 mouse.
Similar articles
-
Estimation of individual uptake of trichloroethylene, 1,1,1-trichloroethane and tetrachloroethylene from biological parameters.Int Arch Occup Environ Health. 1979 Jan 15;42(3-4):319-23. doi: 10.1007/BF00377786. Int Arch Occup Environ Health. 1979. PMID: 422273 No abstract available.
-
Difference in uptake, elimination, and metabolism in exposure to trichloroethylene, 1,1,1-trichloroethane and tetrachloroethylene.Int Arch Occup Environ Health. 1979 Jan 15;42(3-4):311-7. doi: 10.1007/BF00377785. Int Arch Occup Environ Health. 1979. PMID: 422272 No abstract available.
-
Toxicity of Perchloroethylene, Trichloroethylene, 1,1,1-trichloroethane, and Methylene Chloride to Fathead Minnows.Bull Environ Contam Toxicol. 1978 Sep;20(3):344-52. doi: 10.1007/BF01683531. Bull Environ Contam Toxicol. 1978. PMID: 708925 No abstract available.
-
Specific covalent binding and toxicity of aliphatic halogenated xenobiotics.Q Rev Drug Metab Drug Interact. 1982;4(1):1-48. doi: 10.1515/dmdi.1982.4.1.1. Q Rev Drug Metab Drug Interact. 1982. PMID: 6762624 Review. No abstract available.
-
Species differences in carcinogenicity: the role of metabolism and pharmacokinetics in risk assessment.Ann Ist Super Sanita. 1991;27(4):595-9. Ann Ist Super Sanita. 1991. PMID: 1820731 Review.