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. 2022:2452:227-258.
doi: 10.1007/978-1-0716-2111-0_15.

Animal Models of COVID-19: Nonhuman Primates

Dhiraj K Singh  1   2 , Journey Cole  1   2 , Ruby A Escobedo  1   2 , Kendra J Alfson  2 , Bindu Singh  1   2 , Tae-Hyung Lee  1   2 , Xavier Alvarez  1   2 , Shashank R Ganatra  1   2 , Ricardo Carrion Jr  2 , Deepak Kaushal  3   4
Affiliations

Animal Models of COVID-19: Nonhuman Primates

Dhiraj K Singh et al. Methods Mol Biol. 2022.

Abstract

With the advent of the novel SARS-CoV-2, the entire world has been thrown into chaos with severe disruptions from a normal life. While the entire world was going chaotic, the researchers throughout the world were struggling to contribute to the best of their capabilities to advance the understanding of this new pandemic and fast track the development of novel therapeutics and vaccines. While various animal models have helped a lot to understand the basic physiology, nonhman primates have been promising and much more successful in modelling human diseases compared to other available clinical models. Here we describe the different aspects of modelling the SARS-CoV-2 infection in NHPs along with the associated methods used in NHP immunology.

Keywords: Animal models; BAL; COVID-19; Computed tomography; Cone beam; Confocal microscopy; FACS; Flow cytometry; IHC; In vivo imaging; NHP; Nonhuman primates; Rhesus macaques; SARS-CoV-2; X-rays.

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