Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr;13(2):527-538.
doi: 10.21037/jgo-22-145.

Comparison of prognostic factors of esophageal cancer between a Chinese cohort and the Surveillance, Epidemiology, and End Results (SEER) database: a retrospective cohort study

Bin Hu  1 , Yiyao Zhu  1 , Xiaobo Wu  1
Affiliations

Comparison of prognostic factors of esophageal cancer between a Chinese cohort and the Surveillance, Epidemiology, and End Results (SEER) database: a retrospective cohort study

Bin Hu et al. J Gastrointest Oncol. 2022 Apr.

Abstract

Background: Esophageal cancer is a highly aggressive, early metastasis gastrointestinal malignancy, with geographic differences in prognosis. It is unknown whether there are differences in the survival in different regions among esophageal cancer patients who underwent the treatments. This study was to explore the influencing factors of esophageal cancer survival in patients from China and the Surveillance, Epidemiology, and End Results (SEER) database.

Methods: The retrospective cohort study were conducted with 605 Chinese esophageal cancer patients in the Wuxi People's Hospital and 2,351 patients from the SEER database. The demographic and clinical data were collected from the two cohort, respectively. The outcome was the death during the follow-up. The follow-up ended on November 30, 2021. The Cox proportional hazards model was used in the univariate and multivariate survival analyses, with hazard ratio (HR) and 95% confidence interval (CI).

Results: In group one, the following were identified as the prognostic factors: female gender (HR =0.568; 95% CI: 0.398-0.811), T3 and T4 stages (HR =3.312; 95% CI: 2.493-4.401), N2 and N3 stages (HR =3.562; 95% CI: 2.631-4.824), and other subtypes of cancer (HR =0.393; 95% CI: 0.223-0.693). The following prognostic were factors identified in group two: age ≥65 years (HR =1.16; 95% CI: 1.058-1.276), female gender (HR =0.843; 95% CI: 0.752-0.945), T3 and T4 stages (HR =1.523; 95% CI: 1.373-1.690), M1 stage (HR =2.554; 95% CI: 2.303-2.832), treatment with surgery and chemotherapy (HR =0.507; 95% CI: 0.457-0.562), and other subtypes of cancer (HR =1.432; 95% CI: 1.298-1.581).

Conclusions: There may be some differences in prognostic factors between Chinese and American patients with esophageal cancer. It is indicated that different management strategies of esophageal cancer should be considered in different populations to improve the prognosis of patients.

Keywords: China; Esophageal cancer; Surveillance, Epidemiology, and End Results (SEER); comparison; prognostic factors.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jgo.amegroups.com/article/view/10.21037/jgo-22-145/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
The flow diagram of sample selection in the two groups.
Figure 2
Figure 2
Cumulative incidence of overall survival in group one.
Figure 3
Figure 3
Cumulative incidence of overall survival in group two.
Figure 4
Figure 4
Forest plot for multivariate analysis of patients in group one. SE: standard error; HR: hazard ratio.
Figure 5
Figure 5
Forest plot for multivariate analysis of patients in group two. SE, standard error; HR, hazard ratio.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Watanabe M, Otake R, Kozuki R, et al. Recent progress in multidisciplinary treatment for patients with esophageal cancer. Surg Today 2020;50:12-20. 10.1007/s00595-019-01878-7 - DOI - PMC - PubMed
    1. Ferlay J, Colombet M, Soerjomataram I, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer 2019;144:1941-53. 10.1002/ijc.31937 - DOI - PubMed
    1. Pennathur A, Gibson MK, Jobe BA, et al. Oesophageal carcinoma. Lancet 2013;381:400-12. 10.1016/S0140-6736(12)60643-6 - DOI - PubMed
    1. Li D, Zhang L, Liu Y, et al. Specific DNA methylation markers in the diagnosis and prognosis of esophageal cancer. Aging (Albany NY) 2019;11:11640-58. 10.18632/aging.102569 - DOI - PMC - PubMed
    1. Miyamoto H, Kunisaki C, Sato S, et al. Tumor volume index as a prognostic factor in patients after curative esophageal cancer resection. Ann Surg Oncol 2019;26:1909-15. 10.1245/s10434-019-07308-9 - DOI - PubMed