Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May 9;8(6):e1324.
doi: 10.1097/TXD.0000000000001324. eCollection 2022 Jun.

Influence of Donor Race and Donor-recipient Race-matching on Pediatric Kidney Transplant Outcomes

Kennedy Sun  1 , Pamela Singer  1   2 , Abby Basalely  1   2 , Lawrence Lau  2 , Laura Castellanos  1   2 , Ahmed E Fahmy  2 , Lewis W Teperman  2 , Ernesto P Molmenti  2 , Elliot I Grodstein  2 , Christine B Sethna  1   2
Affiliations

Influence of Donor Race and Donor-recipient Race-matching on Pediatric Kidney Transplant Outcomes

Kennedy Sun et al. Transplant Direct. .

Abstract

Existing literature has demonstrated the significant relationship between race and kidney transplant outcomes; however, there are conflicting and limited data on the influence of donor race or donor-recipient race-matching on pediatric kidney transplant outcomes.

Methods: Analysis included kidney-only transplant recipients between ages 2 and 17 from 2000 to 2017 enrolled in the Organ Procurement and Transplantation Network and their associated donors. Multivariable regression models were used to compare outcomes by donor race and donor-recipient race-matched status.

Results: Of the total 7343 recipients, 4458 (60.7%) recipients received a kidney from a White donor, 1009 (13.7%) from a Black donor, 1594 (21.7%) from Hispanic donor, and 169 (4.1%) from an Asian donor; 4089 (55.7%) were race-matched. No donor races were significantly associated with transplant outcomes (all P > 0.05). Race-matched status was not associated with graft failure (hazard ratio, 1.03; 95% confidence interval [CI] = 0.89-1.2; P = 0.68), mortality (hazard ratio, 1.1; 95% CI, 0.79-1.53; P = 0.56), acute rejection at 1 y (odds ratio, 0.94; 95% CI, 0.77-1.15; P = 0.53), or delayed graft function (odds ratio, 1.02; 95% CI, 0.80-1.29; P = 0.91).

Conclusions: Neither donor race nor race-matched status is associated with better transplant outcomes. Further studies are necessary to confirm the impact of donor race and race-matching more fully on pediatric kidney transplant outcomes.

PubMed Disclaimer

Conflict of interest statement

The authors declare no funding or conflicts of interest.

Figures

FIGURE 1.
FIGURE 1.
Flow chart of the study population.
FIGURE 2.
FIGURE 2.
Kaplan-Meier survival plot and life table for graft failure based on donor race. The recipient survival rate depending on the race of donor was graphed as a function of patient time (in years), which was defined as the time from the day of transplant to last follow-up or death. Log-rank P = 0.027. The table outlines hazard rates and proportions of recipients who survived for 1, 3, 5, and 10 y after the kidney transplant. Tx, transplant.
FIGURE 3.
FIGURE 3.
Kaplan-Meier survival plot and life table for graft survival based on race-matched status. The recipient survival rate depending on the race of donor was graphed as a function of patient time (in years), which was defined as the time from the day of transplant to last follow-up or death. Log-rank P < 0.0001. The table outlines hazard rates and proportions of recipients who survived for 1, 3, 5, and 10 y after the kidney transplant. Tx, transplant.
FIGURE 4.
FIGURE 4.
Kaplan-Meier survival plot and life table for mortality based on donor race. The recipient survival rate depending on the race of donor was graphed as a function of patient time (in years), which was defined as the time from the day of transplant to last follow-up or death. Log-rank P = 0.006. The table outlines hazard rates and proportions of recipients who survived for 1, 3, 5, and 10 y after the kidney transplant. Tx, transplant.
FIGURE 5.
FIGURE 5.
Kaplan-Meier survival plot and life table for mortality based on race-matched status. The recipient survival rate depending on the race of donor was graphed as a function of patient time (in years), which was defined as the time from the day of transplant to last follow-up or death. Log-rank P = 0.144. The table outlines hazard rates and proportions of recipients who survived for 1, 3, 5, and 10 y after the kidney transplant. Tx, transplant.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Shemesh E, Kleinman LC, Howell EA, et al. . Racial and economic disparities in transplant outcomes: the not-so-hidden morbidities. Liver Transpl. 2014;20:4–6. - PMC - PubMed
    1. Flores G; Committee On Pediatric Research. Technical report–racial and ethnic disparities in the health and health care of children. Pediatrics. 2010;125:e979–e1020. - PubMed
    1. Guan I, Singer P, Frank R, et al. . Role of race in kidney transplant outcomes in children with focal segmental glomerulosclerosis. Pediatr Transplant. 2016;20:790–797. - PubMed
    1. Isaacs RB, Nock SL, Spencer CE, et al. . Racial disparities in renal transplant outcomes. AM J Kidney Dis. 1999;34:706–712. - PubMed
    1. Zhou YC, Cecka JM, Terasaki PI. Effect of race on kidney transplants. Clin Transpl. 1990;447–459. - PubMed