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Clinical Trial
. 1978 Aug;41(8):702-6.
doi: 10.1136/jnnp.41.8.702.

Sodium valproate in the treatment of levodopa-induced dyskinesia

P A Price, J D Parkes, C D Marsden
Clinical Trial

Sodium valproate in the treatment of levodopa-induced dyskinesia

P A Price et al. J Neurol Neurosurg Psychiatry. 1978 Aug.

Abstract

The effect of sodium valproate 1200 mg daily on the disability of Parkinsonism and on levodopa-induced dyskinesia was assessed in a double-blind crossover trial with matched placebo in 12 patients with Parkinson's disease. No objective change in the severity of Parkinsonism or dyskinesias was noted. However, six out of nine patients who completed the trial noted a slight to moderate improvement in their dyskinesias with no change in their Parkinsonism. Excess salivation improved in four subjects on sodium valproate.

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References

    1. Psychopharmacology (Berl). 1976 Sep 17;49(2):173-8 - PubMed
    1. Br J Psychiatry. 1976 Aug;129:114-9 - PubMed
    1. Nature. 1976 Oct 21;263(5579):695-6 - PubMed
    1. Brain Res. 1976 Nov 5;116(2):353-9 - PubMed
    1. Lancet. 1973 Dec 29;2(7844):1499-500 - PubMed

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