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Review
. 2022 Oct;60(4):470-476.
doi: 10.1002/uog.24935.

Diffusion tensor imaging of fetal brain: principles, potential and limitations of promising technique

R Corroenne  1   2 , C Arthuis  2   3 , G Kasprian  4 , H Mahallati  5 , Y Ville  1 , A-E Millischer Bellaiche  6 , C Henry  2 , D Grevent  2   6 , L J Salomon  1   2
Affiliations
Free article
Review

Diffusion tensor imaging of fetal brain: principles, potential and limitations of promising technique

R Corroenne et al. Ultrasound Obstet Gynecol. 2022 Oct.
Free article

Abstract

Human brain development is a complex process that begins in the third week of gestation. During early development, the fetal brain undergoes dynamic morphological changes. These changes result from events such as neurogenesis, neuronal migration, synapse formation, axonal growth and myelination. Disruption of any of these processes is thought to be responsible for a wide array of different pathologies. Recent advances in magnetic resonance imaging, especially diffusion-weighted imaging and diffusion tensor imaging (DTI), have enabled characterization and evaluation of brain development in utero. In this review, aimed at practitioners involved in fetal medicine and high-risk pregnancies, we provide a comprehensive overview of fetal DTI studies focusing on characterization of early normal brain development as well as evaluation of brain pathology in utero. We also discuss the reliability and limitations of fetal brain DTI. © 2022 International Society of Ultrasound in Obstetrics and Gynecology.

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References

    1. Bystron I, Blakemore C, Rakic P. Development of the human cerebral cortex: Boulder Committee revisited. Nat Rev Neurosci 2008; 9: 110-122.
    1. Silbereis JC, Pochareddy S, Zhu Y, Li M, Sestan N. The Cellular and Molecular Landscapes of the Developing Human CNS. Neuron 2016; 89: 248.
    1. Sidman RL, Rakic P. Neuronal migration, with special reference to developing human brain: a review. Brain Res 1973; 62: 1-35.
    1. Huttenlocher PR, Dabholkar AS. Regional differences in synaptogenesis in human cerebral cortex. J Comp Neurol 1997; 387: 167-178.
    1. Innocenti GM, Price DJ. Exuberance in the development of cortical networks. Nat Rev Neurosci 2005; 6: 955-965.

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