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. 2023 May 19;88(10):6523-6531.
doi: 10.1021/acs.joc.2c00712. Epub 2022 May 13.

Organophotoredox-Catalyzed Reductive Tetrafluoroalkylation of Alkenes

Vladislav S Kostromitin  1   2 , Vitalij V Levin  1 , Alexander D Dilman  1
Affiliations

Organophotoredox-Catalyzed Reductive Tetrafluoroalkylation of Alkenes

Vladislav S Kostromitin et al. J Org Chem. .

Abstract

A method for the hydroperfluoroalkylation of alkenes with 1,2-dibromotetrafluoroethane leading to tetrafluorinated bromides is described. The reaction is conveniently performed under blue light irradiation using an organic photocatalyst and ascorbic acid as a reducing agent. Primary products can be further functionalized via radical pathways affording various tetrafluorinated compounds.

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