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Review
. 2022 May 16;60(8):1136-1144.
doi: 10.1515/cclm-2022-0277. Print 2022 Jul 26.

Perinatal presepsin assessment: a new sepsis diagnostic tool?

Valentina Botondi  1 , Ebe D'Adamo  1 , Mario Plebani  2 , Oriana Trubiani  3 , Marika Perrotta  1 , Laura Di Ricco  1 , Cynzia Spagnuolo  1 , Sara De Sanctis  1 , Elisabetta Barbante  1 , Maria Chiara Strozzi  4 , Antonio Maconi  4 , Francesca Gazzolo  5 , Marta Betti  4 , Annalisa Roveta  4 , Gabriella Levantini  1 , Diego Gazzolo  1
Affiliations
Free article
Review

Perinatal presepsin assessment: a new sepsis diagnostic tool?

Valentina Botondi et al. Clin Chem Lab Med. .
Free article

Abstract

Perinatal sepsis constitutes a medical emergency and is still one of the major causes of mortality and morbidity. The possibility of an early diagnosis of sepsis is still debated and controversial. In particular, clinical symptoms can be hidden by the association of sepsis with other perinatal diseases and/or by therapeutic strategies performed. In this context, there is evidence that the accuracy of standard of care diagnostic parameters (i.e. blood culture, C-reactive protein, procalcitonin) can be biased by additional confounding factors (gestational age, birth-weight, acute-chronic hypoxia). Therefore, the inclusion in clinical daily practice of new biomarkers of sepsis is of utmost importance. Of a panel of biomarkers, Presepsin (P-SEP) plays an important role in the development and response of the immune system and as an early marker of sepsis both in adult and pediatric patients. Therefore, in the present review we aim to offer an overview of the role of P-SEP in the early detection of perinatal sepsis as a trustworthy marker according to actual statements of official international institutions. Future perspectives regard the possibility of a longitudinal non-invasive biological fluids P-SEP assessment thus limiting the sample stress in high risk newborns.

Keywords: newborns; presepsin; sCD14; sepsis.

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