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. 2022 Aug;240(7-8):1957-1966.
doi: 10.1007/s00221-022-06373-z. Epub 2022 May 13.

Essential tremor impairs the ability to suppress involuntary action impulses

Jessi M Kane  1   2 , Jessica L McDonnell  1 , Joseph S Neimat  1 , Peter Hedera  3   4 , Wery P M van den Wildenberg  5   6 , Fenna T Phibbs  4 , Elise B Bradley  4 , Scott A Wylie  1 , Nelleke C van Wouwe  7   8
Affiliations

Essential tremor impairs the ability to suppress involuntary action impulses

Jessi M Kane et al. Exp Brain Res. 2022 Aug.

Abstract

Essential tremor (ET) is a movement disorder characterized primarily by action tremor which affects the regulation of movements. Disruptions in cerebello-thalamocortical networks could interfere with cognitive control over actions in ET, for example, the ability to suppress a strong automatic impulse over a more appropriate action (conflict control). The current study investigated whether ET impacts conflict control proficiency. Forty-one ET patients and 29 age-matched healthy controls (HCs) performed a conflict control task (Simon task). Participants were instructed to give a left or right response to a spatially lateralized arrow (direction of the arrow). When the action signaled by the spatial location and direction of the arrow were non-corresponding (induced conflict), the inappropriate action impulse required suppression. Overall, ET patients responded slower and less accurately compared to HCs. ET patients were especially less accurate on non-corresponding conflict (Nc) versus corresponding (Cs) trials. A focused analysis on fast impulsive response rates (based on the accuracy rate at the fastest reaction times on Nc trials) showed that ET patients made more fast errors compared to HCs. Results suggest impaired conflict control in ET compared to HCs. The increased impulsive errors seen in the ET population may be a symptom of deficiencies in the cerebello-thalamocortical networks, or, be caused by indirect effects on the cortico-striatal pathways. Future studies into the functional networks impacted by ET (cortico-striatal and cerebello-thalamocortical pathways) could advance our understanding of inhibitory control in general and the cognitive deficits in ET.

Keywords: Cerebellum; Cognitive control; Conflict control; Essential tremor; Movement disorder.

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Conflict of interest statement

Declarations

Conflict of interest On behalf of all authors, the corresponding author states that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Mean RTs (A) and accuracy rates (B) on corresponding (Cs) and noncorresponding (Nc) trial types for ET patients and HC. Error bars reflect standard error of the mean
Fig. 1
Fig. 1
Mean RTs (A) and accuracy rates (B) on corresponding (Cs) and noncorresponding (Nc) trial types for ET patients and HC. Error bars reflect standard error of the mean
Fig. 2
Fig. 2
Conditional accuracy functions for corresponding (A, Cs) and non-corresponding (B, Nc) trial types for ET patients and HC
Fig. 2
Fig. 2
Conditional accuracy functions for corresponding (A, Cs) and non-corresponding (B, Nc) trial types for ET patients and HC
Fig. 3
Fig. 3
RT delta plots for ET patients and HC. Each bin contains the same number of trials, averaged across the subjects in each subgroup
See this image and copyright information in PMC

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